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• W4200358445 abstract "Human cytomegalo virus (CMV) is widespread in the human population (prevalence 50% to close to 100%) and can cause severe, often life-threatening diseases in all conditions with a missing or weak immune system. Patients at risk include recipients of stem cells or solid organs, newborns, AIDS patients, and potentially also patients in intensive care or patients treated aggressively against certain autoimmune disorders and cancers. Until 2017, all licensed low molecular weight drugs against CMV addressed the viral polymerase as their target and – by interaction with human polymerases – are burdened with significant side effects like bone marrow toxicity, kidney toxicity, mutagenicity, or carcinogenicity. In addition, cross-resistance between these drugs developed, leaving patients without therapeutic options. In this chapter, the discovery of inhibitors of the CMV viral terminase will be described. Based on the fact that this target does not have any counterpart in humans, these drugs have proven to be very well tolerated. They exert high efficacy and by addressing a different target show no cross-resistance to polymerase inhibitors against CMV. For the first time, therefore, prophylaxis against CMV reactivation is now possible for recipients of hematopoietic stem cells. The use of letermovir for CMV prophylaxis in kidney recipients is currently being investigated. Furthermore, the role as a potential co-pathogen, which this widespread virus is suspected to play in a number of the conditions mentioned above, can now be characterized by clinical studies. In cases, where an important role of CMV as co-pathogen becomes evident, this may allow to introduce treatment against CMV as part of the management of the condition." @default.
• W4200358445 created "2021-12-31" @default.
• W4200358445 creator A5004530281 @default.
• W4200358445 date "2021-12-03" @default.
• W4200358445 modified "2023-09-26" @default.
• W4200358445 title "Antiviral Strategies Against the Human Cytomegalo Virus" @default.
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• W4200358445 doi "https://doi.org/10.1002/9783527810697.ch6" @default.
• W4200358445 hasPublicationYear "2021" @default.
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