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- W4200362783 abstract "• The C1-C2 Schiff bases were synthesized from easily available bromo salicylaldehyde and amino acids viz., arginine and histidine. • The Schiff bases were easily prepared at room temperature (72.1 0 F). • Both the Schiff bases were selectively binds with fatal carcinogen Pb 2+ ions in aqueous medium. • Pb 2+ binding with amino acids in aqueous media is useful for in vivo studies on drug discovery for cancer. Lead toxicity is the never-ending and everyday growing problem of the world. It is reported to be a life-threatening poison for infants and children. Although the number of receptors are reported in the literature the wildness of toxicity is intense, which is somewhat like the ever-increasing gap between demand and supply. The C1 (2-[(5-Bromo-2-hydroxy benzylidene)-amino]-3 -(1H-imidazol-4-yl)-propionic acid) and C2 (2-Amino-5-[N'-(5-bromo-2-hydroxy-benzylidene)-guanidino]-pentanoic acid) were prepared to test their capability as lead (Pb) sensors. The probes C1 and C2 were synthesized by treating bromo salicylaldehyde with amino acids histidine and arginine at room temperature. The Schiff bases formed show significant binding with Pb 2+ ions in the aqueous medium. The lowest detection limit is 20 ng/ml of both sensors. As lead toxicity is fatal to infants and kids and both amino acids viz., arginine and histidine are a common component of total parental nutrition in infants and kids. Thus, amino acids substituted C1-C2 probes are of great significance for the development of molecular drugs to treat lead poisoning especially in infants, and extensively for the human body." @default.
- W4200362783 created "2021-12-31" @default.
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- W4200362783 date "2022-02-01" @default.
- W4200362783 modified "2023-09-27" @default.
- W4200362783 title "Schiff bases bearing amino acids for selective detection of Pb2+ ions in aqueous medium" @default.
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- W4200362783 doi "https://doi.org/10.1016/j.cplett.2021.139280" @default.
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