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- W4200364073 abstract "Abstract Microplastic contamination has received increasing attention in recent years, and concern regarding the toxicity of microplastics to the environment and humans has increased. In this study, we investigated the neurodevelopmental toxicity of polystyrene microplastics (PSMPs) in the zebrafish Danio rerio under different exposure scenario. We investigated the effect of early life exposure to PSMPs on responses later in life, under different exposure scenarios. Zebrafish were exposed to PSMPs during embrionic stage, then allowed the fish to recover. The neurodevelopmental toxic responses were investigated using fish behavior and behavior-related gene expression. Early life exposure to PSMPs did not alter fish behavior at the early stage, however, it led to hyperactivity later life-stage. Generally, oxidative stress (i.e. sod2 and nrf2a ) and nervous system (i.e. slc6a4b, npy and nrbf2) -related gene expression increased in all PSMPs-exposed fish. DNA hypomethylation was observed in fish challenged for a second time using the same PSMPs. Taken together, the current results imply that PSMPs have neurodevelopmental toxic potential when introduced early in life." @default.
- W4200364073 created "2021-12-31" @default.
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- W4200364073 date "2021-11-23" @default.
- W4200364073 modified "2023-09-28" @default.
- W4200364073 title "Effect of Early Life Exposure of Polystyrene Microplastics on Behavior and DNA Methylation in Later Life Stage of Zebrafish" @default.
- W4200364073 doi "https://doi.org/10.21203/rs.3.rs-1091379/v1" @default.
- W4200364073 hasPublicationYear "2021" @default.
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