FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200366948> ?p ?o ?g. }

• W4200366948 endingPage "S260" @default.
• W4200366948 startingPage "S260" @default.
• W4200366948 abstract "Abstract Background Rescue ECMO has been used worldwide in patients (pts) with ARDS caused by COVID-19. Bacterial super-infections affect 3.5-14.3% of hospitalized pts with COVID-19. Pts requiring ECMO may be at an increased risk of infection due to their severity of illness, gut translocation and ECMO impact on host immunity. Methods This was a retrospective review of pts requiring ECMO for COVID-19 from April 2020-2021 at a single center. Strict definitions of infections (including ventilator-associated PNA, VAP) were in accordance with CDC criteria. Results 43 ECMO pts with 1065 ECMO days were evaluated. Median age was 53 yrs (range: 21-62) and median BMI was 36.2 (range: 19.4-75.8). 70% were men and 65% were white. 37 patients (86%) experienced a total of 40 infectious episodes with a median onset from ECMO cannulation to first infection of 10.5d (range: 4-50). Median SOFA and SAPSII scores at time of infection were 12 (6-20) and 63 (30-90), respectively. PNA was the most common infection (78%, with 19% of cases complicated by bacteremia and 3% by empyema) (Fig. 1). The most common organisms isolated were Enterobacterales (37%), S. aureus (25%) and P. aeruginosa (16%) (Fig. 2). Only 2% of all organisms were multi-drug resistant. 3 pts had fungal infections (1 candidemia, 2 aspergillus PNA). Duration of ECMO was significantly longer for infected pts (26d, range: 5-92d) vs (11d, range: 3-24d), p=.01. 95% of infected pts had received steroids vs. 67% of uninfected pts, p=0.09. Treatment success at 1 week was 50%, and 24% and 40% of pts had recurrent infections and persistent/recurrent organisms in clinical cultures, respectively. S. aureus (54%) and Enterobacterales (26%) were associated with persistent or recurrent clinical cultures, requiring prolonged antimicrobial therapy. Mortality rate at 30 days was 65% and was significantly higher for pts with infection than those without (67% vs 33%, p=.02). Conclusion Super-infection (most commonly PNA) occurred in almost all COVID-19 pts requiring ECMO for &gt;4 days, and was a significant risk factor for death. Recurrent infections among survivors were common, especially when caused by Enterbacterales or S. aureus. Super-infection and mortality rates of ARDS pts on ECMO for COVID-19 were worse than for ARDS pts on ECMO for influenza at our center. Disclosures Ryan K. Shields, PharmD, MS, Shionogi (Consultant, Research Grant or Support) Fernanda P. Silveira, MD, MS, FIDSA, Ansun (Individual(s) Involved: Self): Grant/Research Support; Novartis (Individual(s) Involved: Self): Grant/Research Support; Qiagen (Individual(s) Involved: Self): Grant/Research Support; Shire (Individual(s) Involved: Self): Advisor or Review Panel member, Grant/Research Support; SlieaGen (Individual(s) Involved: Self): Grant/Research Support; Whiscon (Individual(s) Involved: Self): Grant/Research Support Cornelius J. Clancy, MD, Merck (Grant/Research Support)" @default.
• W4200366948 created "2021-12-31" @default.
• W4200366948 creator A5005239178 @default.
• W4200366948 creator A5016846242 @default.
• W4200366948 creator A5024677215 @default.
• W4200366948 creator A5039296570 @default.
• W4200366948 creator A5041589225 @default.
• W4200366948 creator A5054008840 @default.
• W4200366948 creator A5056565182 @default.
• W4200366948 creator A5059942127 @default.
• W4200366948 creator A5074182672 @default.
• W4200366948 creator A5081382082 @default.
• W4200366948 creator A5090336151 @default.
• W4200366948 date "2021-11-01" @default.
• W4200366948 modified "2023-09-27" @default.
• W4200366948 title "308. Secondary Infections in Patients Requiring Extracorporeal Membrane Oxygenation (ECMO) for Severe Acute Respiratory Distress Syndrome (ARDS) due to COVID-19 Pneumonia (PNA)" @default.
• W4200366948 doi "https://doi.org/10.1093/ofid/ofab466.510" @default.
• W4200366948 hasPublicationYear "2021" @default.
• W4200366948 type Work @default.
• W4200366948 citedByCount "0" @default.
• W4200366948 crossrefType "journal-article" @default.
• W4200366948 hasAuthorship W4200366948A5005239178 @default.
• W4200366948 hasAuthorship W4200366948A5016846242 @default.
• W4200366948 hasAuthorship W4200366948A5024677215 @default.
• W4200366948 hasAuthorship W4200366948A5039296570 @default.
• W4200366948 hasAuthorship W4200366948A5041589225 @default.
• W4200366948 hasAuthorship W4200366948A5054008840 @default.
• W4200366948 hasAuthorship W4200366948A5056565182 @default.
• W4200366948 hasAuthorship W4200366948A5059942127 @default.
• W4200366948 hasAuthorship W4200366948A5074182672 @default.
• W4200366948 hasAuthorship W4200366948A5081382082 @default.
• W4200366948 hasAuthorship W4200366948A5090336151 @default.
• W4200366948 hasBestOaLocation W42003669481 @default.
• W4200366948 hasConcept C126322002 @default.
• W4200366948 hasConcept C141071460 @default.
• W4200366948 hasConcept C167135981 @default.
• W4200366948 hasConcept C2776348555 @default.
• W4200366948 hasConcept C2776858399 @default.
• W4200366948 hasConcept C2777714996 @default.
• W4200366948 hasConcept C2777914695 @default.
• W4200366948 hasConcept C2779443120 @default.
• W4200366948 hasConcept C501593827 @default.
• W4200366948 hasConcept C71924100 @default.
• W4200366948 hasConcept C86803240 @default.
• W4200366948 hasConcept C89423630 @default.
• W4200366948 hasConceptScore W4200366948C126322002 @default.
• W4200366948 hasConceptScore W4200366948C141071460 @default.
• W4200366948 hasConceptScore W4200366948C167135981 @default.
• W4200366948 hasConceptScore W4200366948C2776348555 @default.
• W4200366948 hasConceptScore W4200366948C2776858399 @default.
• W4200366948 hasConceptScore W4200366948C2777714996 @default.
• W4200366948 hasConceptScore W4200366948C2777914695 @default.
• W4200366948 hasConceptScore W4200366948C2779443120 @default.
• W4200366948 hasConceptScore W4200366948C501593827 @default.
• W4200366948 hasConceptScore W4200366948C71924100 @default.
• W4200366948 hasConceptScore W4200366948C86803240 @default.
• W4200366948 hasConceptScore W4200366948C89423630 @default.
• W4200366948 hasIssue "Supplement_1" @default.
• W4200366948 hasLocation W42003669481 @default.
• W4200366948 hasLocation W42003669482 @default.
• W4200366948 hasOpenAccess W4200366948 @default.
• W4200366948 hasPrimaryLocation W42003669481 @default.
• W4200366948 hasRelatedWork W2045701287 @default.
• W4200366948 hasRelatedWork W2469559411 @default.
• W4200366948 hasRelatedWork W2524940502 @default.
• W4200366948 hasRelatedWork W2910638862 @default.
• W4200366948 hasRelatedWork W3092371503 @default.
• W4200366948 hasRelatedWork W3121432628 @default.
• W4200366948 hasRelatedWork W3131850829 @default.
• W4200366948 hasRelatedWork W4205166663 @default.
• W4200366948 hasRelatedWork W4282961208 @default.
• W4200366948 hasRelatedWork W4310816504 @default.
• W4200366948 hasVolume "8" @default.
• W4200366948 isParatext "false" @default.
• W4200366948 isRetracted "false" @default.
• W4200366948 workType "article" @default.