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• W4200366998 abstract "<ns3:p>Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm generated by reciprocal chromosomal translocation, t (9; 22) (q34; q11) in the transformed hematopoietic stem cell. Tyrosine kinase inhibitors (TKIs) target the mature proliferating BCR-ABL cells, the major CML driver, and increase overall and disease-free survival. However, mutant clones, pre-existing or due to therapy, develop resistance against TKIs. BCR-ABL1 oncoprotein activates various molecular pathways including the RAS/RAF/MEK/ERK pathway, JAK2/STAT pathway, and PI3K/AKT/mTOR pathway. Stimulation of these pathways in TKI resistant CML patients, make them a new target. Moreover, a small proportion of CML cells, leukemic stem cells (LSCs), persist during the TKI therapy and sustain the disease in the patient. Engraftment of LSCs in the bone marrow niche and dysregulation of miRNA participate greatly in the TKI resistance. Current efforts are needed for determining the reason behind TKI resistance, identification, and elimination of CML LSC might be of great need for cancer cure.</ns3:p>" @default.
• W4200366998 created "2021-12-31" @default.
• W4200366998 creator A5083658231 @default.
• W4200366998 date "2021-12-15" @default.
• W4200366998 modified "2023-09-27" @default.
• W4200366998 title "Contribution of BCR-ABL molecular variants and leukemic stem cells in response and resistance to tyrosine kinase inhibitors: a review" @default.
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• W4200366998 cites W1995670055 @default.
• W4200366998 cites W1998593414 @default.
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• W4200366998 doi "https://doi.org/10.12688/f1000research.74570.1" @default.
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