Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200370296> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W4200370296 endingPage "332" @default.
- W4200370296 startingPage "325" @default.
- W4200370296 abstract "Hepatocellular carcinoma (HCC) is a common indication for liver transplantation (LT), but post-LT tumor recurrence remains a concern. Early post-LT immunosuppression is suggested to affect recurrence risk. We evaluated the impact on HCC recurrence of an immunosuppression protocol introduced in 2010 with interleukin-2 receptor antibody (IL-2RA) induction and delayed-introduction of reduced-dose tacrolimus with mycophenolate.We included consecutive HCC patients transplanted 2000-2017 in Gothenburg. The impact on HCC recurrence of IL-2RA induction and mean tacrolimus trough concentration during the first 20 post-LT days was analyzed by multivariable Cox regression and propensity score-adjusted analyses.The study comprised 235 patients (mean age 57 yrs, men 80%, mean MELD 13, within Milan criteria 57%). The cumulative 5-yr HCC recurrence rate among patients transplanted before and after 2010 were 28.6% and 19.7%, respectively. IL-2RA induction had no independent effect on HCC recurrence. High tacrolimus exposure (mean 20-day tacrolimus concentration ≥8ng/mL) was associated with increased HCC recurrence risk on univariable analysis (HR 2.22, 95% CI 1.23-4.01, p = .008), but was non-significant on multivariable analysis (p = .17). Outside Milan criteria, high tacrolimus exposure was significant for HCC recurrence (HR 3.68, 95% CI 1.34-10.11, p = .012) independently of tumor characteristics and AFP level. This was confirmed on multivariable propensity score-adjusted analysis.Reduced early tacrolimus exposure, facilitated by IL-2RA induction, was associated with reduced risk for HCC recurrence among patients outside Milan criteria. Prospective studies are needed to confirm if early tacrolimus-minimization strategies can help reduce HCC recurrence rates and help extend transplant criteria." @default.
- W4200370296 created "2021-12-31" @default.
- W4200370296 creator A5003318457 @default.
- W4200370296 creator A5005510232 @default.
- W4200370296 creator A5008662566 @default.
- W4200370296 creator A5023309608 @default.
- W4200370296 creator A5036417849 @default.
- W4200370296 date "2021-12-06" @default.
- W4200370296 modified "2023-09-30" @default.
- W4200370296 title "Reduced calcineurin inhibitor exposure with antibody induction and recurrent hepatocellular carcinoma after liver transplantation" @default.
- W4200370296 cites W1601739679 @default.
- W4200370296 cites W1705690831 @default.
- W4200370296 cites W1835183346 @default.
- W4200370296 cites W1963919405 @default.
- W4200370296 cites W1969472163 @default.
- W4200370296 cites W1982257612 @default.
- W4200370296 cites W2002403551 @default.
- W4200370296 cites W2006179292 @default.
- W4200370296 cites W2040393718 @default.
- W4200370296 cites W2057587361 @default.
- W4200370296 cites W2058092607 @default.
- W4200370296 cites W2061059105 @default.
- W4200370296 cites W2072413179 @default.
- W4200370296 cites W2079649533 @default.
- W4200370296 cites W2140482093 @default.
- W4200370296 cites W2165846424 @default.
- W4200370296 cites W2277004004 @default.
- W4200370296 cites W2315027248 @default.
- W4200370296 cites W2317451807 @default.
- W4200370296 cites W2321119966 @default.
- W4200370296 cites W2334080029 @default.
- W4200370296 cites W2598444026 @default.
- W4200370296 cites W2802157167 @default.
- W4200370296 cites W2924401293 @default.
- W4200370296 cites W2988471260 @default.
- W4200370296 doi "https://doi.org/10.1080/00365521.2021.2010799" @default.
- W4200370296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34871120" @default.
- W4200370296 hasPublicationYear "2021" @default.
- W4200370296 type Work @default.
- W4200370296 citedByCount "3" @default.
- W4200370296 countsByYear W42003702962023 @default.
- W4200370296 crossrefType "journal-article" @default.
- W4200370296 hasAuthorship W4200370296A5003318457 @default.
- W4200370296 hasAuthorship W4200370296A5005510232 @default.
- W4200370296 hasAuthorship W4200370296A5008662566 @default.
- W4200370296 hasAuthorship W4200370296A5023309608 @default.
- W4200370296 hasAuthorship W4200370296A5036417849 @default.
- W4200370296 hasBestOaLocation W42003702962 @default.
- W4200370296 hasConcept C126322002 @default.
- W4200370296 hasConcept C128057223 @default.
- W4200370296 hasConcept C188816634 @default.
- W4200370296 hasConcept C2776282453 @default.
- W4200370296 hasConcept C2778019345 @default.
- W4200370296 hasConcept C2779609443 @default.
- W4200370296 hasConcept C2780252810 @default.
- W4200370296 hasConcept C2909675724 @default.
- W4200370296 hasConcept C2911091166 @default.
- W4200370296 hasConcept C50382708 @default.
- W4200370296 hasConcept C71924100 @default.
- W4200370296 hasConcept C90924648 @default.
- W4200370296 hasConceptScore W4200370296C126322002 @default.
- W4200370296 hasConceptScore W4200370296C128057223 @default.
- W4200370296 hasConceptScore W4200370296C188816634 @default.
- W4200370296 hasConceptScore W4200370296C2776282453 @default.
- W4200370296 hasConceptScore W4200370296C2778019345 @default.
- W4200370296 hasConceptScore W4200370296C2779609443 @default.
- W4200370296 hasConceptScore W4200370296C2780252810 @default.
- W4200370296 hasConceptScore W4200370296C2909675724 @default.
- W4200370296 hasConceptScore W4200370296C2911091166 @default.
- W4200370296 hasConceptScore W4200370296C50382708 @default.
- W4200370296 hasConceptScore W4200370296C71924100 @default.
- W4200370296 hasConceptScore W4200370296C90924648 @default.
- W4200370296 hasIssue "3" @default.
- W4200370296 hasLocation W42003702961 @default.
- W4200370296 hasLocation W42003702962 @default.
- W4200370296 hasLocation W42003702963 @default.
- W4200370296 hasLocation W42003702964 @default.
- W4200370296 hasOpenAccess W4200370296 @default.
- W4200370296 hasPrimaryLocation W42003702961 @default.
- W4200370296 hasRelatedWork W1542595140 @default.
- W4200370296 hasRelatedWork W1981243282 @default.
- W4200370296 hasRelatedWork W2057587361 @default.
- W4200370296 hasRelatedWork W2079649533 @default.
- W4200370296 hasRelatedWork W2083124691 @default.
- W4200370296 hasRelatedWork W2351127253 @default.
- W4200370296 hasRelatedWork W2971690211 @default.
- W4200370296 hasRelatedWork W3043938996 @default.
- W4200370296 hasRelatedWork W4213432307 @default.
- W4200370296 hasRelatedWork W4232720482 @default.
- W4200370296 hasVolume "57" @default.
- W4200370296 isParatext "false" @default.
- W4200370296 isRetracted "false" @default.
- W4200370296 workType "article" @default.