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- W4200370422 abstract "A species-specific lipidome profile is an inherent feature linked to longevity in the animal kingdom. However, there is a lack of lipidomic studies on human longevity. Here, we use mass spectrometry-based lipidomics to detect and quantify 151 sphingolipid molecular species and use these to define a phenotype of healthy humans with exceptional life span. Our results demonstrate that this profile specifically comprises a higher content of complex glycosphingolipids (hexosylceramides and gangliosides), and lower levels of ceramide species from the de novo pathway, sphingomyelin and sulfatide; while for ceramide-derived signaling compounds, their content remains unchanged. Our findings suggest that structural glycosphingolipids may be more relevant to achieve the centenarian condition than signaling sphingolipids." @default.
- W4200370422 created "2021-12-31" @default.
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- W4200370422 date "2021-12-05" @default.
- W4200370422 modified "2023-10-16" @default.
- W4200370422 title "Long-lived Humans Have a Unique Plasma Sphingolipidome" @default.
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- W4200370422 doi "https://doi.org/10.1093/gerona/glab360" @default.
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