Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200370777> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4200370777 abstract "Abstract Alveolar soft part sarcoma (ASPS) is a soft part malignancy affecting adolescents and young adults. ASPS is characterized by a highly integrated vascular network, and its high metastatic potential indicates the importance of ASPS’s prominent angiogenic activity. Here, we found that the expression of ASPSCR1-TFE3, the fusion transcription factor causatively associated with ASPS, is dispensable for in vitro tumor maintenance; however, it is required for in vivo tumor development via angiogenesis. ASPSCR1-TFE3 is frequently associated with super-enhancers (SEs) upon its DNA binding, and the loss of its expression induces SE-distribution dynamic modification related to genes belonging to the angiogenesis pathway. Using epigenomic CRISPR/dCas9 screening, we identified Pdgfb, Rab27a, Sytl2, and Vwf as critical targets associated with reduced enhancer activities due to the ASPSCR1-TFE3 loss. Upregulation of Rab27a and Sytl2 promotes angiogenic factor-trafficking to facilitate ASPS vascular network construction. ASPSCR1-TFE3 thus orchestrates higher ordered angiogenesis via modulating the SE activity." @default.
- W4200370777 created "2021-12-31" @default.
- W4200370777 creator A5001807716 @default.
- W4200370777 creator A5014139412 @default.
- W4200370777 creator A5014963443 @default.
- W4200370777 creator A5015427845 @default.
- W4200370777 creator A5015974477 @default.
- W4200370777 creator A5016375050 @default.
- W4200370777 creator A5017715797 @default.
- W4200370777 creator A5023730666 @default.
- W4200370777 creator A5036671946 @default.
- W4200370777 creator A5059050136 @default.
- W4200370777 creator A5064777387 @default.
- W4200370777 creator A5076512316 @default.
- W4200370777 creator A5085135396 @default.
- W4200370777 date "2021-12-27" @default.
- W4200370777 modified "2023-10-18" @default.
- W4200370777 title "ASPSCR1-TFE3 orchestrates the angiogenic program of alveolar soft part sarcoma" @default.
- W4200370777 doi "https://doi.org/10.21203/rs.3.rs-1144566/v1" @default.
- W4200370777 hasPublicationYear "2021" @default.
- W4200370777 type Work @default.
- W4200370777 citedByCount "0" @default.
- W4200370777 crossrefType "posted-content" @default.
- W4200370777 hasAuthorship W4200370777A5001807716 @default.
- W4200370777 hasAuthorship W4200370777A5014139412 @default.
- W4200370777 hasAuthorship W4200370777A5014963443 @default.
- W4200370777 hasAuthorship W4200370777A5015427845 @default.
- W4200370777 hasAuthorship W4200370777A5015974477 @default.
- W4200370777 hasAuthorship W4200370777A5016375050 @default.
- W4200370777 hasAuthorship W4200370777A5017715797 @default.
- W4200370777 hasAuthorship W4200370777A5023730666 @default.
- W4200370777 hasAuthorship W4200370777A5036671946 @default.
- W4200370777 hasAuthorship W4200370777A5059050136 @default.
- W4200370777 hasAuthorship W4200370777A5064777387 @default.
- W4200370777 hasAuthorship W4200370777A5076512316 @default.
- W4200370777 hasAuthorship W4200370777A5085135396 @default.
- W4200370777 hasBestOaLocation W42003707771 @default.
- W4200370777 hasConcept C104317684 @default.
- W4200370777 hasConcept C111936080 @default.
- W4200370777 hasConcept C121912465 @default.
- W4200370777 hasConcept C127561419 @default.
- W4200370777 hasConcept C142724271 @default.
- W4200370777 hasConcept C150194340 @default.
- W4200370777 hasConcept C170493617 @default.
- W4200370777 hasConcept C180361614 @default.
- W4200370777 hasConcept C190727270 @default.
- W4200370777 hasConcept C207001950 @default.
- W4200370777 hasConcept C2775960820 @default.
- W4200370777 hasConcept C2777666782 @default.
- W4200370777 hasConcept C2778256501 @default.
- W4200370777 hasConcept C2779399171 @default.
- W4200370777 hasConcept C2780394083 @default.
- W4200370777 hasConcept C2780545995 @default.
- W4200370777 hasConcept C35555191 @default.
- W4200370777 hasConcept C502942594 @default.
- W4200370777 hasConcept C54355233 @default.
- W4200370777 hasConcept C71924100 @default.
- W4200370777 hasConcept C86339819 @default.
- W4200370777 hasConcept C86803240 @default.
- W4200370777 hasConcept C95444343 @default.
- W4200370777 hasConceptScore W4200370777C104317684 @default.
- W4200370777 hasConceptScore W4200370777C111936080 @default.
- W4200370777 hasConceptScore W4200370777C121912465 @default.
- W4200370777 hasConceptScore W4200370777C127561419 @default.
- W4200370777 hasConceptScore W4200370777C142724271 @default.
- W4200370777 hasConceptScore W4200370777C150194340 @default.
- W4200370777 hasConceptScore W4200370777C170493617 @default.
- W4200370777 hasConceptScore W4200370777C180361614 @default.
- W4200370777 hasConceptScore W4200370777C190727270 @default.
- W4200370777 hasConceptScore W4200370777C207001950 @default.
- W4200370777 hasConceptScore W4200370777C2775960820 @default.
- W4200370777 hasConceptScore W4200370777C2777666782 @default.
- W4200370777 hasConceptScore W4200370777C2778256501 @default.
- W4200370777 hasConceptScore W4200370777C2779399171 @default.
- W4200370777 hasConceptScore W4200370777C2780394083 @default.
- W4200370777 hasConceptScore W4200370777C2780545995 @default.
- W4200370777 hasConceptScore W4200370777C35555191 @default.
- W4200370777 hasConceptScore W4200370777C502942594 @default.
- W4200370777 hasConceptScore W4200370777C54355233 @default.
- W4200370777 hasConceptScore W4200370777C71924100 @default.
- W4200370777 hasConceptScore W4200370777C86339819 @default.
- W4200370777 hasConceptScore W4200370777C86803240 @default.
- W4200370777 hasConceptScore W4200370777C95444343 @default.
- W4200370777 hasLocation W42003707771 @default.
- W4200370777 hasLocation W42003707772 @default.
- W4200370777 hasOpenAccess W4200370777 @default.
- W4200370777 hasPrimaryLocation W42003707771 @default.
- W4200370777 hasRelatedWork W2039710236 @default.
- W4200370777 hasRelatedWork W2108921615 @default.
- W4200370777 hasRelatedWork W2350670584 @default.
- W4200370777 hasRelatedWork W2375648105 @default.
- W4200370777 hasRelatedWork W2439301799 @default.
- W4200370777 hasRelatedWork W2742809649 @default.
- W4200370777 hasRelatedWork W3178515596 @default.
- W4200370777 hasRelatedWork W4200370777 @default.
- W4200370777 hasRelatedWork W4362697080 @default.
- W4200370777 hasRelatedWork W1921181437 @default.
- W4200370777 isParatext "false" @default.
- W4200370777 isRetracted "false" @default.
- W4200370777 workType "article" @default.