Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200370797> ?p ?o ?g. }
- W4200370797 abstract "Abstract The existing treatments for somatoform dysfunction (SfD), reaction to severe stress (RSS), and adjustment disorders (AjD) are insufficiently effective and safe. Anxiolytic drug Tenoten proved effective in clinical trials (CT). The aim of this multicenter double-blind placebo-controlled randomized CT was to investigate the safety and efficacy of Tenoten in the treatment of anxiety in adults with SfD, RSS, AjD and other neurotic disorders (oNDs). 390 adult patients with SfD, RSS and AjD or oNDs with the Hospital Anxiety and Depression scale-anxiety (HADS-A) score ≥ 11 were randomized into 4 groups (n = 127 in Tenoten group 1 (4 tablets/day); n = 131 in Tenoten group 3 (8 tablets/day), n = 132 in combined Placebo group 2 + 4). The changes from baseline in the mean Hamilton Anxiety Rating Scale (HAM-A) score in groups 1 and 3 after 12 weeks were the primary outcome. The decrease of the HAM-A score from 18.81 ± 5.81 to 7.26 ± 4.63 (in group 1) and from 18.38 ± 4.3 to 6.40 ± 4.02 (in group 3) was observed post-treatment (p group 1/placebo = 0.0055, p group 3/placebo < 0.0001). Overall, 46 adverse events (28 in the Tenoten groups and 18 in the Placebo) were reported without any difference between the study groups. Tenoten performed significantly more effective than placebo in the anxiety treatment of adults with SfD, RSS, AjD and oNDs (clinicaltrials.gov NCT03036293)." @default.
- W4200370797 created "2021-12-31" @default.
- W4200370797 creator A5011857498 @default.
- W4200370797 creator A5013438478 @default.
- W4200370797 creator A5017842381 @default.
- W4200370797 creator A5023986196 @default.
- W4200370797 creator A5035490283 @default.
- W4200370797 creator A5039642227 @default.
- W4200370797 creator A5040516728 @default.
- W4200370797 creator A5053303685 @default.
- W4200370797 creator A5055184096 @default.
- W4200370797 creator A5068287231 @default.
- W4200370797 creator A5073266133 @default.
- W4200370797 creator A5079894069 @default.
- W4200370797 creator A5086450599 @default.
- W4200370797 creator A5091710956 @default.
- W4200370797 date "2021-12-20" @default.
- W4200370797 modified "2023-10-14" @default.
- W4200370797 title "RETRACTED ARTICLE: The randomized clinical trial results of the anxiety treatment in patients with somatoform dysfunction and neurotic disorders" @default.
- W4200370797 cites W126370213 @default.
- W4200370797 cites W1603996513 @default.
- W4200370797 cites W171042215 @default.
- W4200370797 cites W192237198 @default.
- W4200370797 cites W1970123506 @default.
- W4200370797 cites W1974420087 @default.
- W4200370797 cites W1987787559 @default.
- W4200370797 cites W2002258124 @default.
- W4200370797 cites W2052000468 @default.
- W4200370797 cites W2055041380 @default.
- W4200370797 cites W2064711215 @default.
- W4200370797 cites W2100328462 @default.
- W4200370797 cites W2116326578 @default.
- W4200370797 cites W2130726089 @default.
- W4200370797 cites W2139900098 @default.
- W4200370797 cites W2150901658 @default.
- W4200370797 cites W2238577358 @default.
- W4200370797 cites W2323889115 @default.
- W4200370797 cites W2414595603 @default.
- W4200370797 cites W2563677121 @default.
- W4200370797 cites W2752484779 @default.
- W4200370797 cites W2789490845 @default.
- W4200370797 cites W2901168657 @default.
- W4200370797 cites W2916625049 @default.
- W4200370797 cites W2981020663 @default.
- W4200370797 cites W2982634790 @default.
- W4200370797 cites W3018813552 @default.
- W4200370797 cites W3045721183 @default.
- W4200370797 cites W4244813130 @default.
- W4200370797 doi "https://doi.org/10.1038/s41598-021-03727-5" @default.
- W4200370797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34930979" @default.
- W4200370797 hasPublicationYear "2021" @default.
- W4200370797 type Work @default.
- W4200370797 citedByCount "3" @default.
- W4200370797 countsByYear W42003707972022 @default.
- W4200370797 crossrefType "journal-article" @default.
- W4200370797 hasAuthorship W4200370797A5011857498 @default.
- W4200370797 hasAuthorship W4200370797A5013438478 @default.
- W4200370797 hasAuthorship W4200370797A5017842381 @default.
- W4200370797 hasAuthorship W4200370797A5023986196 @default.
- W4200370797 hasAuthorship W4200370797A5035490283 @default.
- W4200370797 hasAuthorship W4200370797A5039642227 @default.
- W4200370797 hasAuthorship W4200370797A5040516728 @default.
- W4200370797 hasAuthorship W4200370797A5053303685 @default.
- W4200370797 hasAuthorship W4200370797A5055184096 @default.
- W4200370797 hasAuthorship W4200370797A5068287231 @default.
- W4200370797 hasAuthorship W4200370797A5073266133 @default.
- W4200370797 hasAuthorship W4200370797A5079894069 @default.
- W4200370797 hasAuthorship W4200370797A5086450599 @default.
- W4200370797 hasAuthorship W4200370797A5091710956 @default.
- W4200370797 hasBestOaLocation W42003707971 @default.
- W4200370797 hasConcept C118552586 @default.
- W4200370797 hasConcept C126322002 @default.
- W4200370797 hasConcept C138496976 @default.
- W4200370797 hasConcept C139719470 @default.
- W4200370797 hasConcept C142724271 @default.
- W4200370797 hasConcept C15744967 @default.
- W4200370797 hasConcept C162324750 @default.
- W4200370797 hasConcept C168563851 @default.
- W4200370797 hasConcept C1862650 @default.
- W4200370797 hasConcept C187288502 @default.
- W4200370797 hasConcept C204787440 @default.
- W4200370797 hasConcept C27081682 @default.
- W4200370797 hasConcept C2776867660 @default.
- W4200370797 hasConcept C558461103 @default.
- W4200370797 hasConcept C71924100 @default.
- W4200370797 hasConcept C77805123 @default.
- W4200370797 hasConcept C83849319 @default.
- W4200370797 hasConcept C94612546 @default.
- W4200370797 hasConceptScore W4200370797C118552586 @default.
- W4200370797 hasConceptScore W4200370797C126322002 @default.
- W4200370797 hasConceptScore W4200370797C138496976 @default.
- W4200370797 hasConceptScore W4200370797C139719470 @default.
- W4200370797 hasConceptScore W4200370797C142724271 @default.
- W4200370797 hasConceptScore W4200370797C15744967 @default.
- W4200370797 hasConceptScore W4200370797C162324750 @default.
- W4200370797 hasConceptScore W4200370797C168563851 @default.
- W4200370797 hasConceptScore W4200370797C1862650 @default.
- W4200370797 hasConceptScore W4200370797C187288502 @default.
- W4200370797 hasConceptScore W4200370797C204787440 @default.
- W4200370797 hasConceptScore W4200370797C27081682 @default.