FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200371066> ?p ?o ?g. }

• W4200371066 abstract "Candida species are a leading cause of opportunistic, hospital-associated bloodstream infections with high mortality rates, typically in immunocompromised patients. Several species, including Candida albicans, the most prevalent cause of infection, belong to the monophyletic CUG clade of yeasts. Innate immune cells such as macrophages are crucial for controlling infection, and C. albicans responds to phagocytosis by a coordinated induction of pathways involved in catabolism of nonglucose carbon sources, termed alternative carbon metabolism, which together are essential for virulence. However, the interactions of other CUG clade species with macrophages have not been characterized. Here, we analyzed transcriptional responses to macrophage phagocytosis by six Candida species across a range of virulence and clinical importance. We define a core induced response common to pathogenic and nonpathogenic species alike, heavily weighted to alternative carbon metabolism. One prominent pathogen, Candida parapsilosis, showed species-specific expansion of phagocytosis-responsive genes, particularly metabolite transporters. C. albicans and Candida tropicalis, the other prominent pathogens, also had species-specific responses, but these were largely comprised of functionally uncharacterized genes. Transcriptional analysis of macrophages also demonstrated highly correlated proinflammatory transcriptional responses to different Candida species that were largely independent of fungal viability, suggesting that this response is driven by recognition of conserved cell wall components. This study significantly broadens our understanding of host interactions in CUG clade species, demonstrating that although metabolic plasticity is crucial for virulence in Candida, it alone is not sufficient to confer pathogenicity. Instead, we identify sets of mostly uncharacterized genes that may explain the evolution of pathogenicity. IMPORTANCE Candidiasis is a major fungal infection by Candida species, causing life-threatening invasive disease in immunocompromised patients. C. albicans, which is adapted to commensalism of human mucosae, is the most common cause. While several other species cause infection, most are less prevalent or less virulent. As innate immune cells are the primary defense against Candida infection, we compared the transcriptional responses of C. albicans and related species to phagocytosis by macrophages, to understand the basis of variation in pathogenesis. This response, including the metabolic remodeling required for virulence in C. albicans, was strikingly conserved across the virulence spectrum. Macrophage responses to different species were also highly similar. This study indicates that important elements of host-pathogen interactions in C. albicans are not driven by adaptation to the mammalian host and improves our understanding of pathogenicity in opportunistic fungal species that are understudied but collectively impose a significant threat of their own." @default.
• W4200371066 created "2021-12-31" @default.
• W4200371066 creator A5029586922 @default.
• W4200371066 creator A5043083129 @default.
• W4200371066 creator A5076041024 @default.
• W4200371066 creator A5078040501 @default.
• W4200371066 date "2021-12-21" @default.
• W4200371066 modified "2023-10-05" @default.
• W4200371066 title "Interactions of Both Pathogenic and Nonpathogenic CUG Clade <i>Candida</i> Species with Macrophages Share a Conserved Transcriptional Landscape" @default.
• W4200371066 cites W1513095566 @default.
• W4200371066 cites W1599051410 @default.
• W4200371066 cites W1647692986 @default.
• W4200371066 cites W1817988031 @default.
• W4200371066 cites W1968431375 @default.
• W4200371066 cites W1979998554 @default.
• W4200371066 cites W1982281067 @default.
• W4200371066 cites W1988820663 @default.
• W4200371066 cites W1991882850 @default.
• W4200371066 cites W1993727333 @default.
• W4200371066 cites W1995441274 @default.
• W4200371066 cites W1997933706 @default.
• W4200371066 cites W1999574084 @default.
• W4200371066 cites W2012034776 @default.
• W4200371066 cites W2022323546 @default.
• W4200371066 cites W2029128246 @default.
• W4200371066 cites W2032059162 @default.
• W4200371066 cites W2034700901 @default.
• W4200371066 cites W2042161296 @default.
• W4200371066 cites W2049237396 @default.
• W4200371066 cites W2049505636 @default.
• W4200371066 cites W2058315432 @default.
• W4200371066 cites W2060322845 @default.
• W4200371066 cites W2060721894 @default.
• W4200371066 cites W2064487923 @default.
• W4200371066 cites W2082335793 @default.
• W4200371066 cites W2086105638 @default.
• W4200371066 cites W2086514052 @default.
• W4200371066 cites W2090542689 @default.
• W4200371066 cites W2096060313 @default.
• W4200371066 cites W2100014361 @default.
• W4200371066 cites W2100246797 @default.
• W4200371066 cites W2101886337 @default.
• W4200371066 cites W2109962249 @default.
• W4200371066 cites W2110874942 @default.
• W4200371066 cites W2116721311 @default.
• W4200371066 cites W2123087870 @default.
• W4200371066 cites W2123106337 @default.
• W4200371066 cites W2124442776 @default.
• W4200371066 cites W2124863746 @default.
• W4200371066 cites W2126734055 @default.
• W4200371066 cites W2130410032 @default.
• W4200371066 cites W2131271579 @default.
• W4200371066 cites W2133214296 @default.
• W4200371066 cites W2133465414 @default.
• W4200371066 cites W2134909835 @default.
• W4200371066 cites W2135707527 @default.
• W4200371066 cites W2135962353 @default.
• W4200371066 cites W2137402648 @default.
• W4200371066 cites W2138947616 @default.
• W4200371066 cites W2141563676 @default.
• W4200371066 cites W2148931210 @default.
• W4200371066 cites W2149714948 @default.
• W4200371066 cites W2152448670 @default.
• W4200371066 cites W2153104382 @default.
• W4200371066 cites W2154236306 @default.
• W4200371066 cites W2157819004 @default.
• W4200371066 cites W2158176003 @default.
• W4200371066 cites W2158217645 @default.
• W4200371066 cites W2166526638 @default.
• W4200371066 cites W2168627344 @default.
• W4200371066 cites W2169456326 @default.
• W4200371066 cites W2169540909 @default.
• W4200371066 cites W2179438025 @default.
• W4200371066 cites W2197124664 @default.
• W4200371066 cites W2211508526 @default.
• W4200371066 cites W2214074259 @default.
• W4200371066 cites W2261682386 @default.
• W4200371066 cites W2432815617 @default.
• W4200371066 cites W2530772399 @default.
• W4200371066 cites W2550262882 @default.
• W4200371066 cites W2563797091 @default.
• W4200371066 cites W2587240328 @default.
• W4200371066 cites W2591098998 @default.
• W4200371066 cites W2592811885 @default.
• W4200371066 cites W2753912808 @default.
• W4200371066 cites W2767031614 @default.
• W4200371066 cites W2783563972 @default.
• W4200371066 cites W2800526695 @default.
• W4200371066 cites W2896513955 @default.
• W4200371066 cites W2899763402 @default.
• W4200371066 cites W2912372472 @default.
• W4200371066 cites W2931152478 @default.
• W4200371066 cites W2939738000 @default.
• W4200371066 cites W2944959421 @default.
• W4200371066 cites W2950221693 @default.
• W4200371066 cites W2951636677 @default.
• W4200371066 cites W2999032278 @default.
• W4200371066 cites W3001477289 @default.
• W4200371066 cites W3001698320 @default.
• W4200371066 cites W3009559434 @default.

• next