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• W4200373216 abstract "Individual reactions to traumatic stress vary dramatically, yet the biological basis of this variation remains poorly understood. Recent studies demonstrate the surprising plasticity of oligodendrocytes and myelin with stress and experience, providing a potential mechanism by which trauma induces aberrant structural and functional changes in the adult brain. In this study, we utilized a translational approach to test the hypothesis that gray matter oligodendrocytes contribute to traumatic-stress-induced behavioral variation in both rats and humans. We exposed adult, male rats to a single, severe stressor and used a multimodal approach to characterize avoidance, startle, and fear-learning behavior, as well as oligodendrocyte and myelin basic protein (MBP) content in multiple brain areas. We found that oligodendrocyte cell density and MBP were correlated with behavioral outcomes in a region-specific manner. Specifically, stress-induced avoidance positively correlated with hippocampal dentate gyrus oligodendrocytes and MBP. Viral overexpression of the oligodendrogenic factor Olig1 in the dentate gyrus was sufficient to induce an anxiety-like behavioral phenotype. In contrast, contextual fear learning positively correlated with MBP in the amygdala and spatial-processing regions of the hippocampus. In a group of trauma-exposed US veterans, T1-/T2-weighted magnetic resonance imaging estimates of hippocampal and amygdala myelin associated with symptom profiles in a region-specific manner that mirrored the findings in rats. These results demonstrate a species-independent relationship between region-specific, gray matter oligodendrocytes and differential behavioral phenotypes following traumatic stress exposure. This study suggests a novel mechanism for brain plasticity that underlies individual variance in sensitivity to traumatic stress." @default.
• W4200373216 created "2021-12-31" @default.
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• W4200373216 date "2021-12-13" @default.
• W4200373216 modified "2023-10-18" @default.
• W4200373216 title "Regional gray matter oligodendrocyte- and myelin-related measures are associated with differential susceptibility to stress-induced behavior in rats and humans" @default.
• W4200373216 cites W170792860 @default.
• W4200373216 cites W1833314573 @default.
• W4200373216 cites W1967937854 @default.
• W4200373216 cites W1975821649 @default.
• W4200373216 cites W1982835526 @default.
• W4200373216 cites W1989982790 @default.
• W4200373216 cites W1993415874 @default.
• W4200373216 cites W1994414964 @default.
• W4200373216 cites W1995185151 @default.
• W4200373216 cites W2001162889 @default.
• W4200373216 cites W2009414958 @default.
• W4200373216 cites W2016095773 @default.
• W4200373216 cites W2018302367 @default.
• W4200373216 cites W2018569342 @default.
• W4200373216 cites W2020315449 @default.
• W4200373216 cites W2021398711 @default.
• W4200373216 cites W2026122266 @default.
• W4200373216 cites W2026123452 @default.
• W4200373216 cites W2026836897 @default.
• W4200373216 cites W2029630254 @default.
• W4200373216 cites W2037476811 @default.
• W4200373216 cites W2038813826 @default.
• W4200373216 cites W2039352738 @default.
• W4200373216 cites W2042287679 @default.
• W4200373216 cites W2042694842 @default.
• W4200373216 cites W2045664047 @default.
• W4200373216 cites W2051578292 @default.
• W4200373216 cites W2056010030 @default.
• W4200373216 cites W2056376421 @default.
• W4200373216 cites W2066277136 @default.
• W4200373216 cites W2066642195 @default.
• W4200373216 cites W2070440962 @default.
• W4200373216 cites W2071446247 @default.
• W4200373216 cites W2073414670 @default.
• W4200373216 cites W2083201121 @default.
• W4200373216 cites W2085529478 @default.
• W4200373216 cites W2085757903 @default.
• W4200373216 cites W2094369625 @default.
• W4200373216 cites W2102430481 @default.
• W4200373216 cites W2109167188 @default.
• W4200373216 cites W2114214919 @default.
• W4200373216 cites W2121072935 @default.
• W4200373216 cites W2123556420 @default.
• W4200373216 cites W2133471348 @default.
• W4200373216 cites W2135438065 @default.
• W4200373216 cites W2140201388 @default.
• W4200373216 cites W2143691247 @default.
• W4200373216 cites W2145787009 @default.
• W4200373216 cites W2148977391 @default.
• W4200373216 cites W2149579330 @default.
• W4200373216 cites W2151337518 @default.
• W4200373216 cites W2154265420 @default.
• W4200373216 cites W2157257192 @default.
• W4200373216 cites W2164220501 @default.
• W4200373216 cites W2167279371 @default.
• W4200373216 cites W2167872155 @default.
• W4200373216 cites W2176978669 @default.
• W4200373216 cites W2187332448 @default.
• W4200373216 cites W2285187319 @default.
• W4200373216 cites W2312140086 @default.
• W4200373216 cites W2320835301 @default.
• W4200373216 cites W2331898567 @default.
• W4200373216 cites W2407313014 @default.
• W4200373216 cites W2409934336 @default.
• W4200373216 cites W2498283353 @default.
• W4200373216 cites W2504550392 @default.
• W4200373216 cites W2607371682 @default.
• W4200373216 cites W2752824298 @default.
• W4200373216 cites W2760892898 @default.
• W4200373216 cites W2766818318 @default.
• W4200373216 cites W2784326790 @default.
• W4200373216 cites W2787419526 @default.
• W4200373216 cites W2793201005 @default.
• W4200373216 cites W2793877036 @default.
• W4200373216 cites W2793877399 @default.
• W4200373216 cites W2795424043 @default.
• W4200373216 cites W2827807866 @default.
• W4200373216 cites W2884854280 @default.

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