FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200375732> ?p ?o ?g. }

• W4200375732 endingPage "115" @default.
• W4200375732 startingPage "91" @default.
• W4200375732 abstract "Ordinary differential equation models are used to represent intracellular signaling pathways in silico, aiding and guiding biological experiments to elucidate intracellular regulation. To construct such quantitative and predictive models of intracellular interactions, unknown parameters need to be estimated. Most of biological data are expressed in relative or arbitrary units, raising the question of how to compare model simulations with data. It has recently been shown that for models with large number of unknown parameters, fitting algorithms using a data-driven normalization of the simulations (DNS) performs best in terms of the convergence time and parameter identifiability. DNS approach compares model simulations and corresponding data both normalized by the same normalization procedure, without requiring additional parameters to be estimated, as necessary for widely used scaling factor-based methods. However, currently there is no parameter estimation software that directly supports DNS. In this chapter, we show how to apply DNS to dynamic models of systems and synthetic biology using PEPSSBI (Parameter Estimation Pipeline for Systems and Synthetic Biology). PEPSSBI is the first software that supports DNS, through algorithmically supported data normalization and objective function construction. PEPSSBI also supports model import using SBML and repeated parameter estimation runs executed in parallel either on a personal computer or a multi-CPU cluster." @default.
• W4200375732 created "2021-12-31" @default.
• W4200375732 creator A5003776093 @default.
• W4200375732 creator A5013465452 @default.
• W4200375732 creator A5040251521 @default.
• W4200375732 creator A5077163269 @default.
• W4200375732 date "2021-12-10" @default.
• W4200375732 modified "2023-10-14" @default.
• W4200375732 title "Relationship Between Dimensionality and Convergence of Optimization Algorithms: A Comparison Between Data-Driven Normalization and Scaling Factor-Based Methods Using PEPSSBI" @default.
• W4200375732 cites W1495660511 @default.
• W4200375732 cites W1509329028 @default.
• W4200375732 cites W1573562249 @default.
• W4200375732 cites W1847315806 @default.
• W4200375732 cites W2001620484 @default.
• W4200375732 cites W2018289835 @default.
• W4200375732 cites W2020684750 @default.
• W4200375732 cites W2032026823 @default.
• W4200375732 cites W2087481108 @default.
• W4200375732 cites W2088637782 @default.
• W4200375732 cites W2101108802 @default.
• W4200375732 cites W2102434872 @default.
• W4200375732 cites W2102653059 @default.
• W4200375732 cites W2107589168 @default.
• W4200375732 cites W2109571753 @default.
• W4200375732 cites W2111817213 @default.
• W4200375732 cites W2113983551 @default.
• W4200375732 cites W2117057692 @default.
• W4200375732 cites W2125615370 @default.
• W4200375732 cites W2130191588 @default.
• W4200375732 cites W2136663003 @default.
• W4200375732 cites W2143784594 @default.
• W4200375732 cites W2143894094 @default.
• W4200375732 cites W2150908245 @default.
• W4200375732 cites W2153921000 @default.
• W4200375732 cites W2155306598 @default.
• W4200375732 cites W2164578725 @default.
• W4200375732 cites W2166071821 @default.
• W4200375732 cites W2166751342 @default.
• W4200375732 cites W2168648059 @default.
• W4200375732 cites W2175715045 @default.
• W4200375732 cites W2179083909 @default.
• W4200375732 cites W2262060930 @default.
• W4200375732 cites W2404737222 @default.
• W4200375732 cites W2472163094 @default.
• W4200375732 cites W2741052609 @default.
• W4200375732 cites W2765845615 @default.
• W4200375732 cites W2951604286 @default.
• W4200375732 cites W3024659207 @default.
• W4200375732 cites W4238726034 @default.
• W4200375732 cites W96334552 @default.
• W4200375732 doi "https://doi.org/10.1007/978-1-0716-1767-0_5" @default.
• W4200375732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34888717" @default.
• W4200375732 hasPublicationYear "2021" @default.
• W4200375732 type Work @default.
• W4200375732 citedByCount "0" @default.
• W4200375732 crossrefType "book-chapter" @default.
• W4200375732 hasAuthorship W4200375732A5003776093 @default.
• W4200375732 hasAuthorship W4200375732A5013465452 @default.
• W4200375732 hasAuthorship W4200375732A5040251521 @default.
• W4200375732 hasAuthorship W4200375732A5077163269 @default.
• W4200375732 hasBestOaLocation W42003757322 @default.
• W4200375732 hasConcept C111030470 @default.
• W4200375732 hasConcept C111919701 @default.
• W4200375732 hasConcept C11413529 @default.
• W4200375732 hasConcept C119857082 @default.
• W4200375732 hasConcept C122770356 @default.
• W4200375732 hasConcept C124101348 @default.
• W4200375732 hasConcept C136886441 @default.
• W4200375732 hasConcept C144024400 @default.
• W4200375732 hasConcept C152662350 @default.
• W4200375732 hasConcept C162984825 @default.
• W4200375732 hasConcept C167928553 @default.
• W4200375732 hasConcept C19165224 @default.
• W4200375732 hasConcept C199360897 @default.
• W4200375732 hasConcept C2777904410 @default.
• W4200375732 hasConcept C41008148 @default.
• W4200375732 hasConcept C45874996 @default.
• W4200375732 hasConcept C60644358 @default.
• W4200375732 hasConcept C73555534 @default.
• W4200375732 hasConcept C86803240 @default.
• W4200375732 hasConcept C87186988 @default.
• W4200375732 hasConcept C8797682 @default.
• W4200375732 hasConceptScore W4200375732C111030470 @default.
• W4200375732 hasConceptScore W4200375732C111919701 @default.
• W4200375732 hasConceptScore W4200375732C11413529 @default.
• W4200375732 hasConceptScore W4200375732C119857082 @default.
• W4200375732 hasConceptScore W4200375732C122770356 @default.
• W4200375732 hasConceptScore W4200375732C124101348 @default.
• W4200375732 hasConceptScore W4200375732C136886441 @default.
• W4200375732 hasConceptScore W4200375732C144024400 @default.
• W4200375732 hasConceptScore W4200375732C152662350 @default.
• W4200375732 hasConceptScore W4200375732C162984825 @default.
• W4200375732 hasConceptScore W4200375732C167928553 @default.
• W4200375732 hasConceptScore W4200375732C19165224 @default.
• W4200375732 hasConceptScore W4200375732C199360897 @default.
• W4200375732 hasConceptScore W4200375732C2777904410 @default.
• W4200375732 hasConceptScore W4200375732C41008148 @default.
• W4200375732 hasConceptScore W4200375732C45874996 @default.

• next