Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200380921> ?p ?o ?g. }
- W4200380921 endingPage "108128652110600" @default.
- W4200380921 startingPage "108128652110600" @default.
- W4200380921 abstract "Experimental studies reveal that the anionic lipid phosphatidic acid (POPA), non-phospholipid cholesterol, and cationic lipid DOTAP inhibit the gating of voltage-sensitive potassium (Kv) channels. Here, we develop a continuum electromechanical model to investigate the interaction of these lipids with the ion channel. Our model suggests that: (i) POPA lipids may restrict the vertical motion of the voltage-sensor domain through direct electrostatic interactions; (ii) cholesterol may oppose the radial motion of the pore domain of the channel by increasing the mechanical rigidity of the membrane; and (iii) DOTAP can reduce the effect of electrostatic forces by regulating the dielectric constant at the channel–lipid interface. The electromechanical model predictions for the three lipid types match well with the experimental observations and provide mechanistic insights into lipid-dependent gating of Kv channels." @default.
- W4200380921 created "2021-12-31" @default.
- W4200380921 creator A5060275052 @default.
- W4200380921 creator A5061747940 @default.
- W4200380921 creator A5073462781 @default.
- W4200380921 date "2021-12-29" @default.
- W4200380921 modified "2023-09-27" @default.
- W4200380921 title "Electromechanics of lipid-modulated gating of potassium channels" @default.
- W4200380921 cites W1106171373 @default.
- W4200380921 cites W1969129798 @default.
- W4200380921 cites W1975725416 @default.
- W4200380921 cites W1983519301 @default.
- W4200380921 cites W1983520523 @default.
- W4200380921 cites W1989644593 @default.
- W4200380921 cites W1999108741 @default.
- W4200380921 cites W1999805574 @default.
- W4200380921 cites W2005496553 @default.
- W4200380921 cites W2010718509 @default.
- W4200380921 cites W2022309859 @default.
- W4200380921 cites W2027407318 @default.
- W4200380921 cites W2032734987 @default.
- W4200380921 cites W2040816544 @default.
- W4200380921 cites W2042799855 @default.
- W4200380921 cites W2043483978 @default.
- W4200380921 cites W2046251770 @default.
- W4200380921 cites W2050786281 @default.
- W4200380921 cites W2059571424 @default.
- W4200380921 cites W2065204180 @default.
- W4200380921 cites W2066134897 @default.
- W4200380921 cites W2090091933 @default.
- W4200380921 cites W2094316817 @default.
- W4200380921 cites W2099567685 @default.
- W4200380921 cites W2102321409 @default.
- W4200380921 cites W2106670341 @default.
- W4200380921 cites W2107872165 @default.
- W4200380921 cites W2117172999 @default.
- W4200380921 cites W2118560848 @default.
- W4200380921 cites W2129537918 @default.
- W4200380921 cites W2134047940 @default.
- W4200380921 cites W2138447484 @default.
- W4200380921 cites W2142094786 @default.
- W4200380921 cites W2144420181 @default.
- W4200380921 cites W2151443000 @default.
- W4200380921 cites W2162483141 @default.
- W4200380921 cites W2163025802 @default.
- W4200380921 cites W2177024335 @default.
- W4200380921 cites W2346822460 @default.
- W4200380921 cites W2622346504 @default.
- W4200380921 cites W2903534151 @default.
- W4200380921 cites W2909181336 @default.
- W4200380921 cites W3035437145 @default.
- W4200380921 cites W4232772234 @default.
- W4200380921 doi "https://doi.org/10.1177/10812865211060071" @default.
- W4200380921 hasPublicationYear "2021" @default.
- W4200380921 type Work @default.
- W4200380921 citedByCount "0" @default.
- W4200380921 crossrefType "journal-article" @default.
- W4200380921 hasAuthorship W4200380921A5060275052 @default.
- W4200380921 hasAuthorship W4200380921A5061747940 @default.
- W4200380921 hasAuthorship W4200380921A5073462781 @default.
- W4200380921 hasBestOaLocation W42003809212 @default.
- W4200380921 hasConcept C12554922 @default.
- W4200380921 hasConcept C170493617 @default.
- W4200380921 hasConcept C173424598 @default.
- W4200380921 hasConcept C185592680 @default.
- W4200380921 hasConcept C192562407 @default.
- W4200380921 hasConcept C194544171 @default.
- W4200380921 hasConcept C2776909261 @default.
- W4200380921 hasConcept C2778918659 @default.
- W4200380921 hasConcept C39944091 @default.
- W4200380921 hasConcept C41625074 @default.
- W4200380921 hasConcept C50254741 @default.
- W4200380921 hasConcept C55493867 @default.
- W4200380921 hasConcept C83743174 @default.
- W4200380921 hasConcept C86803240 @default.
- W4200380921 hasConceptScore W4200380921C12554922 @default.
- W4200380921 hasConceptScore W4200380921C170493617 @default.
- W4200380921 hasConceptScore W4200380921C173424598 @default.
- W4200380921 hasConceptScore W4200380921C185592680 @default.
- W4200380921 hasConceptScore W4200380921C192562407 @default.
- W4200380921 hasConceptScore W4200380921C194544171 @default.
- W4200380921 hasConceptScore W4200380921C2776909261 @default.
- W4200380921 hasConceptScore W4200380921C2778918659 @default.
- W4200380921 hasConceptScore W4200380921C39944091 @default.
- W4200380921 hasConceptScore W4200380921C41625074 @default.
- W4200380921 hasConceptScore W4200380921C50254741 @default.
- W4200380921 hasConceptScore W4200380921C55493867 @default.
- W4200380921 hasConceptScore W4200380921C83743174 @default.
- W4200380921 hasConceptScore W4200380921C86803240 @default.
- W4200380921 hasFunder F4320337391 @default.
- W4200380921 hasLocation W42003809211 @default.
- W4200380921 hasLocation W42003809212 @default.
- W4200380921 hasLocation W42003809213 @default.
- W4200380921 hasOpenAccess W4200380921 @default.
- W4200380921 hasPrimaryLocation W42003809211 @default.
- W4200380921 hasRelatedWork W1718469558 @default.
- W4200380921 hasRelatedWork W2002540382 @default.
- W4200380921 hasRelatedWork W2011827753 @default.