Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200381153> ?p ?o ?g. }
- W4200381153 endingPage "2727" @default.
- W4200381153 startingPage "2718" @default.
- W4200381153 abstract "The negative effect of mastitis on lactation is well established, yet the mechanisms causing reduced milk production in the afflicted dairy cow are not. As one of the major inflammatory diseases in the dairy industry, mastitis has rightly received considerable research interest for decades. However, the focus on distinct, pathologic effects in mastitic glands has largely overlooked systemic effects on noninflamed mammary glands. This is particularly evident in the severe, acute response to the potent inflammatory mediator, lipopolysaccharide (LPS). Whereas secretory cell death, impaired tight junctions, and migration of leukocytes are locally restricted to an inflamed, LPS-challenged gland, changes in milk yield and milk components may be detectable in all mammary glands. Further, these differences extend to the mammary transcriptome. Notably, few transcriptomic studies have been designed to test for effects of systemic mediators of inflammation on gene expression. Relevant changes in the noninflamed mammary gland, identified through biochemical analyses and transcriptional studies, warrant further research. Current evidence suggests proinflammatory cytokines play a role in regulating lactose synthesis, but additional candidates and mechanisms continue to be identified. Ultimately, understanding how systemic mediators of inflammation affect mammary function may lead to the development of interventions that enable more efficient milk production without sacrificing the benefits of inflammation." @default.
- W4200381153 created "2021-12-31" @default.
- W4200381153 creator A5013811104 @default.
- W4200381153 creator A5018259855 @default.
- W4200381153 date "2022-03-01" @default.
- W4200381153 modified "2023-10-18" @default.
- W4200381153 title "Graduate Student Literature Review: Systemic mediators of inflammation during mastitis and the search for mechanisms underlying impaired lactation" @default.
- W4200381153 cites W1484377079 @default.
- W4200381153 cites W183265407 @default.
- W4200381153 cites W1964710766 @default.
- W4200381153 cites W1968783711 @default.
- W4200381153 cites W1970341806 @default.
- W4200381153 cites W1974972880 @default.
- W4200381153 cites W1975151442 @default.
- W4200381153 cites W1980054550 @default.
- W4200381153 cites W1983220630 @default.
- W4200381153 cites W1984983574 @default.
- W4200381153 cites W1988955093 @default.
- W4200381153 cites W1993213190 @default.
- W4200381153 cites W1993633260 @default.
- W4200381153 cites W1995487187 @default.
- W4200381153 cites W1996150839 @default.
- W4200381153 cites W2008081537 @default.
- W4200381153 cites W2023234780 @default.
- W4200381153 cites W2026509760 @default.
- W4200381153 cites W2028057791 @default.
- W4200381153 cites W2031435471 @default.
- W4200381153 cites W2035984110 @default.
- W4200381153 cites W2051660810 @default.
- W4200381153 cites W2053314848 @default.
- W4200381153 cites W2053991080 @default.
- W4200381153 cites W2054967698 @default.
- W4200381153 cites W2055247654 @default.
- W4200381153 cites W2067871789 @default.
- W4200381153 cites W2071337143 @default.
- W4200381153 cites W2074150439 @default.
- W4200381153 cites W2093758411 @default.
- W4200381153 cites W2102845785 @default.
- W4200381153 cites W2104997370 @default.
- W4200381153 cites W2107195564 @default.
- W4200381153 cites W2113680353 @default.
- W4200381153 cites W2114426583 @default.
- W4200381153 cites W2117457279 @default.
- W4200381153 cites W2118507136 @default.
- W4200381153 cites W2120334214 @default.
- W4200381153 cites W2121539824 @default.
- W4200381153 cites W2122054271 @default.
- W4200381153 cites W2124357835 @default.
- W4200381153 cites W2126295090 @default.
- W4200381153 cites W2127254933 @default.
- W4200381153 cites W2134111762 @default.
- W4200381153 cites W2135073756 @default.
- W4200381153 cites W2136554574 @default.
- W4200381153 cites W2137462629 @default.
- W4200381153 cites W2140934740 @default.
- W4200381153 cites W2146201647 @default.
- W4200381153 cites W2146948320 @default.
- W4200381153 cites W2149002327 @default.
- W4200381153 cites W2154811349 @default.
- W4200381153 cites W2159195608 @default.
- W4200381153 cites W2162400295 @default.
- W4200381153 cites W2194110790 @default.
- W4200381153 cites W2325034987 @default.
- W4200381153 cites W2395725488 @default.
- W4200381153 cites W2399126204 @default.
- W4200381153 cites W2405827575 @default.
- W4200381153 cites W2465985465 @default.
- W4200381153 cites W2560739253 @default.
- W4200381153 cites W2565024804 @default.
- W4200381153 cites W2802016023 @default.
- W4200381153 cites W2809687868 @default.
- W4200381153 cites W2959270192 @default.
- W4200381153 cites W3031261861 @default.
- W4200381153 cites W3125933322 @default.
- W4200381153 cites W3165794104 @default.
- W4200381153 cites W2102770955 @default.
- W4200381153 doi "https://doi.org/10.3168/jds.2021-20776" @default.
- W4200381153 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34955254" @default.
- W4200381153 hasPublicationYear "2022" @default.
- W4200381153 type Work @default.
- W4200381153 citedByCount "5" @default.
- W4200381153 countsByYear W42003811532022 @default.
- W4200381153 countsByYear W42003811532023 @default.
- W4200381153 crossrefType "journal-article" @default.
- W4200381153 hasAuthorship W4200381153A5013811104 @default.
- W4200381153 hasAuthorship W4200381153A5018259855 @default.
- W4200381153 hasBestOaLocation W42003811531 @default.
- W4200381153 hasConcept C104317684 @default.
- W4200381153 hasConcept C121608353 @default.
- W4200381153 hasConcept C126322002 @default.
- W4200381153 hasConcept C134018914 @default.
- W4200381153 hasConcept C142724271 @default.
- W4200381153 hasConcept C150194340 @default.
- W4200381153 hasConcept C162317418 @default.
- W4200381153 hasConcept C164027704 @default.
- W4200381153 hasConcept C203014093 @default.
- W4200381153 hasConcept C2107291 @default.
- W4200381153 hasConcept C2776252253 @default.