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• W4200384802 endingPage "153060" @default.
• W4200384802 startingPage "153060" @default.
• W4200384802 abstract "With the increasing application of cell culture models as primary tools for predicting chemical safety, the quantitative extrapolation of the effective dose from in vitro to in vivo (QIVIVE) is of increasing importance. For developmental toxicity this requires scaling the in vitro observed dose-response characteristics to in vivo fetal exposure, while integrating maternal in vivo kinetics during pregnancy, in particular transplacental transfer. Here the transfer of substances across the placental barrier, has been studied using the in vitro BeWo cell assay and six embryotoxic compounds of different kinetic complexity. The BeWo assay results were incorporated in an existing generic Physiologically Based Kinetic (PBK) model which for this purpose was extended with rat pregnancy. Finally, as a proof of principle, the BeWo PBK model was used to perform a QIVIVE based on developmental toxicity as observed in various different in vitro toxicity assays. The BeWo results illustrated different transport profiles of the chemicals across the BeWo monolayer, allocating the substances into two distinct groups: the 'quickly-transported' and the 'slowly-transported'. BeWo PBK exposure simulations during gestation were compared to experimentally measured maternal blood and fetal concentrations and a reverse dosimetry approach was applied to translate in vitro observed embryotoxicity into equivalent in vivo dose-response curves. This approach allowed for a direct comparison of the in vitro dose-response characteristics as observed in the Whole Embryo Culture (WEC), and the Embryonic Stem Cell test (cardiac:ESTc and neural:ESTn) with in vivo rat developmental toxicity data. Overall, the in vitro to in vivo comparisons suggest a promising future for the application of such QIVIVE methodologies for screening and prioritization purposes of developmental toxicants. Nevertheless, the clear need for further improvements is acknowledged for a wider application of the approach in chemical safety assessment." @default.
• W4200384802 created "2021-12-31" @default.
• W4200384802 creator A5010620767 @default.
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• W4200384802 date "2022-01-01" @default.
• W4200384802 modified "2023-10-18" @default.
• W4200384802 title "Integrating in vitro chemical transplacental passage into a generic PBK model: A QIVIVE approach" @default.
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• W4200384802 cites W1566175382 @default.
• W4200384802 cites W1574554412 @default.
• W4200384802 cites W186124017 @default.
• W4200384802 cites W1948938001 @default.
• W4200384802 cites W1966092761 @default.
• W4200384802 cites W1967866094 @default.
• W4200384802 cites W1976596494 @default.
• W4200384802 cites W1979728686 @default.
• W4200384802 cites W1980693614 @default.
• W4200384802 cites W1982215549 @default.
• W4200384802 cites W1986813124 @default.
• W4200384802 cites W1990711550 @default.
• W4200384802 cites W1993601532 @default.
• W4200384802 cites W2010011313 @default.
• W4200384802 cites W2010686219 @default.
• W4200384802 cites W2011203208 @default.
• W4200384802 cites W2012777643 @default.
• W4200384802 cites W2013869094 @default.
• W4200384802 cites W2014869287 @default.
• W4200384802 cites W2015342482 @default.
• W4200384802 cites W2017890053 @default.
• W4200384802 cites W2018711002 @default.
• W4200384802 cites W2025226012 @default.
• W4200384802 cites W2025477509 @default.
• W4200384802 cites W2027344439 @default.
• W4200384802 cites W2035976525 @default.
• W4200384802 cites W2036453518 @default.
• W4200384802 cites W2040117889 @default.
• W4200384802 cites W2040258497 @default.
• W4200384802 cites W2045892866 @default.
• W4200384802 cites W2049079962 @default.
• W4200384802 cites W2055596045 @default.
• W4200384802 cites W2057078756 @default.
• W4200384802 cites W2071857756 @default.
• W4200384802 cites W2078758468 @default.
• W4200384802 cites W2078990199 @default.
• W4200384802 cites W2083264198 @default.
• W4200384802 cites W2086294280 @default.
• W4200384802 cites W2087853819 @default.
• W4200384802 cites W2099009726 @default.
• W4200384802 cites W2111411438 @default.
• W4200384802 cites W2111473430 @default.
• W4200384802 cites W2115578358 @default.
• W4200384802 cites W2115883503 @default.
• W4200384802 cites W2127676159 @default.
• W4200384802 cites W2141761586 @default.
• W4200384802 cites W2144323524 @default.
• W4200384802 cites W2146732052 @default.
• W4200384802 cites W2150655565 @default.
• W4200384802 cites W2153076819 @default.
• W4200384802 cites W2158847005 @default.
• W4200384802 cites W2160711073 @default.
• W4200384802 cites W2162097198 @default.
• W4200384802 cites W2164464258 @default.
• W4200384802 cites W2165380591 @default.
• W4200384802 cites W2169461167 @default.
• W4200384802 cites W2170173246 @default.
• W4200384802 cites W2190936842 @default.
• W4200384802 cites W2306934036 @default.
• W4200384802 cites W2325388334 @default.
• W4200384802 cites W2341647963 @default.
• W4200384802 cites W2404597399 @default.
• W4200384802 cites W2522497821 @default.
• W4200384802 cites W2534932042 @default.
• W4200384802 cites W2546948247 @default.
• W4200384802 cites W2547048002 @default.
• W4200384802 cites W2554148381 @default.
• W4200384802 cites W2594159580 @default.
• W4200384802 cites W2699204617 @default.
• W4200384802 cites W2741336735 @default.
• W4200384802 cites W2757307583 @default.
• W4200384802 cites W2769958143 @default.
• W4200384802 cites W2783542718 @default.
• W4200384802 cites W2811329289 @default.
• W4200384802 cites W2904118266 @default.
• W4200384802 cites W2963802744 @default.
• W4200384802 cites W2968383860 @default.
• W4200384802 cites W2998263869 @default.
• W4200384802 cites W3014379094 @default.
• W4200384802 cites W4234324271 @default.
• W4200384802 cites W4317926850 @default.
• W4200384802 doi "https://doi.org/10.1016/j.tox.2021.153060" @default.
• W4200384802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34871708" @default.
• W4200384802 hasPublicationYear "2022" @default.
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