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- W4200387002 abstract "Global implementation of messenger RNA (mRNA) vaccines represents an enormous advance with far-reaching implications for respiratory disease treatment. mRNA vaccines offer exceptional efficacy and versatile capacity to be adapted to new viruses and variants; however, critical questions remain regarding immune persistence and formulation stability. This represents a significant opportunity for developing next-generation, inhaled mRNA vaccines with the ability to drive long-lasting, tissue-specific memory responses needed for rapid recall and immediate local protection. Advances in pulmonary delivery technologies offer potential to overcome translational challenges including design of aerosol-stable and lung-stable formulations, navigation of pulmonary biological barriers, and a lack of predictive models and measurement techniques. We highlight recent advances in each of these challenge areas to illuminate the path to translation." @default.
- W4200387002 created "2021-12-31" @default.
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- W4200387002 date "2022-04-01" @default.
- W4200387002 modified "2023-10-15" @default.
- W4200387002 title "Inhalable mRNA vaccines for respiratory diseases: a roadmap" @default.
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- W4200387002 doi "https://doi.org/10.1016/j.copbio.2021.10.017" @default.
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