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- W4200391805 abstract "The history of N-acetylcysteine (NAC) began with its clinical use as a mucolytic agent in the 1960s. The increase in hepatotoxicity secondary to acetaminophen overdose in the 1960s and 1970s prompted a search for an antidote. A series of key discoveries in the pathophysiology of acetaminophen-induced hepatotoxicity from the National Institutes of Health (NIH) elucidated critical components required of an antidote to mitigate acetaminophen’s toxicity: the presence of a sulfhydryl group and the ability to replete glutathione stores. Work out of the United Kingdom and the United States found NAC to be superior to other sulfhydryl containing compounds in preventing hepatotoxicity secondary to acetaminophen poisoning. The United States was limited to the oral formulation of NAC due to federal regulation whereas the intravenous (IV) formulation was advocated for by investigators in the United Kingdom. In 2004, the IV formulation was approved for use in the United States." @default.
- W4200391805 created "2021-12-31" @default.
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- W4200391805 date "2022-01-01" @default.
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- W4200391805 title "N-Acetylcysteine" @default.
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- W4200391805 doi "https://doi.org/10.1016/b978-0-12-822218-8.00002-8" @default.
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