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- W4200393806 abstract "Abstract Perturbation to the cerebellum can lead to motor dysfunction, cognitive deficits, and behavioral inflexibility. Here we report that a cerebellum-specific transgenic mouse model with disrupted Purkinje cell function shows unexpectedly accelerated learning on a sensory evidence-accumulation task, as well as enhanced sensory reactivity to touch and auditory cues. Computational latent-state analysis of behavior revealed that accelerated learning was associated with enhanced focus on current over past trials. Learning was also accelerated by providing cue-locked optogenetic stimulation of Purkinje cells, but unaffected by continuous optogenetic interference with Purkinje cell activity. Both transgenic and optogenetically-boosted mice showed prolonged electrophysiological activity in Purkinje-cell complex spikes and anterior cingulate cortex. We suggest that cerebellar activity may shape evidence-accumulation learning by enhancing task focus and neocortical processing of current experience." @default.
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- W4200393806 date "2021-12-24" @default.
- W4200393806 modified "2023-09-27" @default.
- W4200393806 title "Cerebellar acceleration of learning in an evidence-accumulation task" @default.
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- W4200393806 doi "https://doi.org/10.1101/2021.12.23.474034" @default.
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