Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200394080> ?p ?o ?g. }
- W4200394080 endingPage "104" @default.
- W4200394080 startingPage "104" @default.
- W4200394080 abstract "The survival and prognosis of hepatocellular carcinoma (HCC) are poor, mainly due to metastasis. Therefore, insights into the molecular mechanisms underlying HCC invasion and metastasis are urgently needed to develop a more effective antimetastatic therapy. Here, we report that KIAA1217, a functionally unknown macromolecular protein, plays a crucial role in HCC metastasis. KIAA1217 expression was frequently upregulated in HCC cell lines and tissues, and high KIAA1217 expression was closely associated with shorter survival of patients with HCC. Overexpression and knockdown experiments revealed that KIAA1217 significantly promoted cell migration and invasion by inducing epithelial-mesenchymal transition (EMT) in vitro. Consistently, HCC cells overexpressing KIAA1217 exhibited markedly enhanced lung metastasis in vivo. Mechanistically, KIAA1217 enhanced EMT and accordingly promoted HCC metastasis by interacting with and activating JAK1/2 and STAT3. Interestingly, KIAA1217-activated p-STAT3 was retained in the cytoplasm instead of translocating into the nucleus, where p-STAT3 subsequently activated the Notch and Wnt/β-catenin pathways to facilitate EMT induction and HCC metastasis. Collectively, KIAA1217 may function as an adaptor protein or scaffold protein in the cytoplasm and coordinate multiple pathways to promote EMT-induced HCC metastasis, indicating its potential as a therapeutic target for curbing HCC metastasis." @default.
- W4200394080 created "2021-12-31" @default.
- W4200394080 creator A5008609733 @default.
- W4200394080 creator A5013419536 @default.
- W4200394080 creator A5020070866 @default.
- W4200394080 creator A5020147975 @default.
- W4200394080 creator A5023307885 @default.
- W4200394080 creator A5025167286 @default.
- W4200394080 creator A5031315906 @default.
- W4200394080 creator A5037269917 @default.
- W4200394080 creator A5041554294 @default.
- W4200394080 creator A5046643126 @default.
- W4200394080 creator A5049798193 @default.
- W4200394080 creator A5055401764 @default.
- W4200394080 creator A5067386111 @default.
- W4200394080 creator A5074056720 @default.
- W4200394080 creator A5083411426 @default.
- W4200394080 creator A5087757321 @default.
- W4200394080 date "2021-12-22" @default.
- W4200394080 modified "2023-09-28" @default.
- W4200394080 title "KIAA1217 Promotes Epithelial-Mesenchymal Transition and Hepatocellular Carcinoma Metastasis by Interacting with and Activating STAT3" @default.
- W4200394080 cites W1587807025 @default.
- W4200394080 cites W1602300277 @default.
- W4200394080 cites W19153779 @default.
- W4200394080 cites W1964847767 @default.
- W4200394080 cites W1967140449 @default.
- W4200394080 cites W2001183293 @default.
- W4200394080 cites W2063011414 @default.
- W4200394080 cites W2068084277 @default.
- W4200394080 cites W2084863590 @default.
- W4200394080 cites W2104193042 @default.
- W4200394080 cites W2105436095 @default.
- W4200394080 cites W2117692326 @default.
- W4200394080 cites W2164718200 @default.
- W4200394080 cites W2179971431 @default.
- W4200394080 cites W2277004004 @default.
- W4200394080 cites W2345714374 @default.
- W4200394080 cites W2407812106 @default.
- W4200394080 cites W2572077158 @default.
- W4200394080 cites W2607129810 @default.
- W4200394080 cites W2607372803 @default.
- W4200394080 cites W2746697572 @default.
- W4200394080 cites W2765565477 @default.
- W4200394080 cites W2786843484 @default.
- W4200394080 cites W2786987313 @default.
- W4200394080 cites W2921608255 @default.
- W4200394080 cites W2936833956 @default.
- W4200394080 cites W2999417355 @default.
- W4200394080 cites W3000361261 @default.
- W4200394080 cites W3014599953 @default.
- W4200394080 cites W3087200754 @default.
- W4200394080 cites W3097409164 @default.
- W4200394080 cites W3113691894 @default.
- W4200394080 cites W3118790373 @default.
- W4200394080 cites W3128646645 @default.
- W4200394080 cites W3173117420 @default.
- W4200394080 cites W4210774372 @default.
- W4200394080 cites W4232620598 @default.
- W4200394080 cites W4253291531 @default.
- W4200394080 doi "https://doi.org/10.3390/ijms23010104" @default.
- W4200394080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35008530" @default.
- W4200394080 hasPublicationYear "2021" @default.
- W4200394080 type Work @default.
- W4200394080 citedByCount "7" @default.
- W4200394080 countsByYear W42003940802022 @default.
- W4200394080 countsByYear W42003940802023 @default.
- W4200394080 crossrefType "journal-article" @default.
- W4200394080 hasAuthorship W4200394080A5008609733 @default.
- W4200394080 hasAuthorship W4200394080A5013419536 @default.
- W4200394080 hasAuthorship W4200394080A5020070866 @default.
- W4200394080 hasAuthorship W4200394080A5020147975 @default.
- W4200394080 hasAuthorship W4200394080A5023307885 @default.
- W4200394080 hasAuthorship W4200394080A5025167286 @default.
- W4200394080 hasAuthorship W4200394080A5031315906 @default.
- W4200394080 hasAuthorship W4200394080A5037269917 @default.
- W4200394080 hasAuthorship W4200394080A5041554294 @default.
- W4200394080 hasAuthorship W4200394080A5046643126 @default.
- W4200394080 hasAuthorship W4200394080A5049798193 @default.
- W4200394080 hasAuthorship W4200394080A5055401764 @default.
- W4200394080 hasAuthorship W4200394080A5067386111 @default.
- W4200394080 hasAuthorship W4200394080A5074056720 @default.
- W4200394080 hasAuthorship W4200394080A5083411426 @default.
- W4200394080 hasAuthorship W4200394080A5087757321 @default.
- W4200394080 hasBestOaLocation W42003940801 @default.
- W4200394080 hasConcept C104317684 @default.
- W4200394080 hasConcept C121608353 @default.
- W4200394080 hasConcept C127561419 @default.
- W4200394080 hasConcept C137620995 @default.
- W4200394080 hasConcept C137738243 @default.
- W4200394080 hasConcept C1491633281 @default.
- W4200394080 hasConcept C173396325 @default.
- W4200394080 hasConcept C190062978 @default.
- W4200394080 hasConcept C2778019345 @default.
- W4200394080 hasConcept C2779013556 @default.
- W4200394080 hasConcept C502942594 @default.
- W4200394080 hasConcept C54355233 @default.
- W4200394080 hasConcept C55493867 @default.
- W4200394080 hasConcept C62478195 @default.