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- W4200398519 startingPage "1492" @default.
- W4200398519 abstract "The tremendous global impact of the current SARS-CoV-2 pandemic, as well as other current and recent outbreaks of (re)emerging viruses, emphasize the need for fast-track development of effective vaccines. Yellow fever virus 17D (YF17D) is a live-attenuated virus vaccine with an impressive efficacy record in humans, and therefore, it is a very attractive platform for the development of novel chimeric vaccines against various pathogens. In the present study, we generated a YF17D-based replicon vaccine platform by replacing the prM and E surface proteins of YF17D with antigenic subdomains from the spike (S) proteins of three different betacoronaviruses: MERS-CoV, SARS-CoV and MHV. The prM and E proteins were provided in trans for the packaging of these RNA replicons into single-round infectious particles capable of expressing coronavirus antigens in infected cells. YF17D replicon particles expressing the S1 regions of the MERS-CoV and SARS-CoV spike proteins were immunogenic in mice and elicited (neutralizing) antibody responses against both the YF17D vector and the coronavirus inserts. Thus, YF17D replicon-based vaccines, and their potential DNA- or mRNA-based derivatives, may constitute a promising and particularly safe vaccine platform for current and future emerging coronaviruses." @default.
- W4200398519 created "2021-12-31" @default.
- W4200398519 creator A5010959513 @default.
- W4200398519 creator A5022991460 @default.
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- W4200398519 creator A5084429609 @default.
- W4200398519 creator A5090665639 @default.
- W4200398519 date "2021-12-16" @default.
- W4200398519 modified "2023-09-28" @default.
- W4200398519 title "A Yellow Fever 17D Virus Replicon-Based Vaccine Platform for Emerging Coronaviruses" @default.
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