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• W4200399461 abstract "Summary Following exocytosis, the recapture of vesicular proteins stranded at the plasma membrane in recycling synaptic vesicles (SVs) is essential to sustain neurotransmission. Nanoclustering is emerging as a mechanism through which proteins may be ‘pre-assembled’ prior to endocytosis, to ensure high fidelity of retrieval for subsequent rounds of vesicle fusion. Here, we used single molecule imaging to examine the nanoclustering of synaptotagmin-1 (Syt1) and synaptic vesicle protein 2A (SV2A). Syt1 forms surface nanoclusters through interaction of its C2B domain (K326/K328) with SV2A, as demonstrated by mutating Syt1 (K326A/K328A) and knocking down endogenous SV2A. Blocking cognate interaction with Syt1 (SV2A T84A ) also decreased SV2A clustering. Impaired nanoclustering of Syt1 and SV2A leads to accelerated endocytosis of Syt1, altered intracellular sorting and decreased trafficking of Syt1 to a Rab5-positive endocytic pathway. We conclude that the interaction between SV2A and Syt1 locks both molecules into surface nanoclusters, controlling their entry into recycling SVs." @default.
• W4200399461 created "2021-12-31" @default.
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• W4200399461 date "2021-12-10" @default.
• W4200399461 modified "2023-10-10" @default.
• W4200399461 title "SV2A-Syt1 interaction controls surface nanoclustering and access to recycling synaptic vesicles" @default.
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• W4200399461 doi "https://doi.org/10.1101/2021.12.08.471864" @default.
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