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Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200404003> ?p ?o ?g. }

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• W4200404003 abstract "To probe into the potential mechanism of microRNA (miR)-98-5p inhibiting the biological progress of cervical cancer (CC) cells via regulating PI3K/Akt pathway. Reverse transcription quantitative polymerase chain reaction was applied to detect miR-98-5p expression in CC tissues and cell lines; Cell counting kit-8 and Edu analysis were performed for checking cell proliferation, flow cytometry for cell apoptosis, transwell for cell invasion and migration, Western blot for proliferation-related proteins Ki67 and Proliferating cell nuclear antigen expression, apoptosis-related proteins Bcl-2 and Bax expression, epithelial-mesenchymal transition (EMT)-related proteins Snail, matrix metalloproteinase-3, E-cadherin and N-cadherin expression, as well as PI3K/Akt pathway-related proteins PTEN, PI3K as well as Akt expression levels, and the nude mouse tumor xenograft experiment was applied to verify in vivo. The result clarified, miR-98-5p was reduced in CC. Overexpression miR-98-5p could inhibit CC cell proliferation, invasion, migration and EMT, whereas promoted its apoptosis, but silencing miR-98-5p was opposite. Overexpression miR-98-5p could depress the activation of PI3K/Akt pathway in CC in vivo and in vitro. MiR-98-5p targeted CBX5. In short, miR-98-5p is able to be used as a potential target for treating CC in future research." @default.
• W4200404003 created "2021-12-31" @default.
• W4200404003 creator A5033020983 @default.
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• W4200404003 date "2021-12-11" @default.
• W4200404003 modified "2023-09-27" @default.
• W4200404003 title "MicroRNA-98-5p modulates cervical cancer progression via controlling PI3K/AKT pathway" @default.
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• W4200404003 doi "https://doi.org/10.1080/21655979.2021.2000722" @default.
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