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- W4200404144 abstract "The intent of current study was formulation and evaluation Al +3 -ions induced ionically gelled cross-linked interpenetrated polymer network (IPN) based microbeads made of homopolymeric blends of carboxymethyl tamarind gum and gellan gum for prolonged sustained release of diclofenac sodium. Spherical diclofenac sodium-loaded carboxymethyl tamarind gum-gellan gum IPN microbeads were accomplished by ionic gelation technique. These microbeads with diameters in the 601–700 μm range demonstrated excellent drug entrapment (34.50 ± 1.05 to 90.54 ± 0.81% efficiency). Fourier transform-infrared, X-ray diffraction and differential scanning calorimetry experiments were used to characterize diclofenac sodium-loaded carboxymethyl tamarind gum-gellan gum IPN microbeads. Various microbeads exhibited prolonged sustained release of diclofenac sodium over 8 h duration and also found to follow the Korsmeyer-Peppas model (R 2 = 0.9937–0.9978). The in vivo pharmacodynamic results suggested the anti-inflammatory effect of diclofenac sodium-loaded carboxymethyl tamarind gum-gellan gum IPN microbeads in a sustained action manner." @default.
- W4200404144 created "2021-12-31" @default.
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- W4200404144 date "2022-03-01" @default.
- W4200404144 modified "2023-09-29" @default.
- W4200404144 title "Gellan gum (GG)-based IPN microbeads for sustained drug release" @default.
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- W4200404144 doi "https://doi.org/10.1016/j.jddst.2021.103034" @default.
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