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- W4200406161 abstract "The presence of complement activation products at sites of pathology in post-mortem Alzheimer's disease (AD) brains is well known. Recent evidence from genome-wide association studies (GWAS), combined with the demonstration that complement activation is pivotal in synapse loss in AD, strongly implicates complement in disease aetiology. Genetic variations in complement genes are widespread. While most variants individually have only minor effects on complement homeostasis, the combined effects of variants in multiple complement genes, referred to as the complotype, can have major effects. In some diseases, the complotype highlights specific parts of the complement pathway involved in disease, thereby pointing towards a mechanism; however, this is not the case with AD. Here we review the complement GWAS hits; CR1 encoding complement receptor 1 (CR1), CLU encoding clusterin, and a suggestive association of C1S encoding the enzyme C1s, and discuss difficulties in attributing the AD association in these genes to complement function. A better understanding of complement genetics in AD might facilitate predictive genetic screening tests and enable the development of simple diagnostic tools and guide the future use of anti-complement drugs, of which several are currently in development for central nervous system disorders." @default.
- W4200406161 created "2021-12-31" @default.
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- W4200406161 creator A5090102833 @default.
- W4200406161 date "2021-12-15" @default.
- W4200406161 modified "2023-10-12" @default.
- W4200406161 title "Genetic Insights into the Impact of Complement in Alzheimer’s Disease" @default.
- W4200406161 cites W1541959720 @default.
- W4200406161 cites W1561580545 @default.
- W4200406161 cites W1589729290 @default.
- W4200406161 cites W1592101872 @default.
- W4200406161 cites W1752389919 @default.
- W4200406161 cites W1765586858 @default.
- W4200406161 cites W1821582401 @default.
- W4200406161 cites W1830808532 @default.
- W4200406161 cites W1963687105 @default.
- W4200406161 cites W1966538236 @default.
- W4200406161 cites W1966831629 @default.
- W4200406161 cites W1966831712 @default.
- W4200406161 cites W1966874118 @default.
- W4200406161 cites W1967176607 @default.
- W4200406161 cites W1971179340 @default.
- W4200406161 cites W1972439404 @default.
- W4200406161 cites W1973014032 @default.
- W4200406161 cites W1974930618 @default.
- W4200406161 cites W1976385354 @default.
- W4200406161 cites W1985524053 @default.
- W4200406161 cites W1999295089 @default.
- W4200406161 cites W2014716434 @default.
- W4200406161 cites W2017453563 @default.
- W4200406161 cites W2018922793 @default.
- W4200406161 cites W2029870992 @default.
- W4200406161 cites W2032230738 @default.
- W4200406161 cites W2038354418 @default.
- W4200406161 cites W2038401787 @default.
- W4200406161 cites W2041393510 @default.
- W4200406161 cites W2055065330 @default.
- W4200406161 cites W2058769645 @default.
- W4200406161 cites W2060877774 @default.
- W4200406161 cites W2063157384 @default.
- W4200406161 cites W2065514214 @default.
- W4200406161 cites W2070716601 @default.
- W4200406161 cites W2077019499 @default.
- W4200406161 cites W2077923419 @default.
- W4200406161 cites W2081046636 @default.
- W4200406161 cites W2090710011 @default.
- W4200406161 cites W2090747948 @default.
- W4200406161 cites W2090968174 @default.
- W4200406161 cites W2092790705 @default.
- W4200406161 cites W2092935640 @default.
- W4200406161 cites W2093064359 @default.
- W4200406161 cites W2093107372 @default.
- W4200406161 cites W2095310635 @default.
- W4200406161 cites W2096327192 @default.
- W4200406161 cites W2097977212 @default.
- W4200406161 cites W2108676263 @default.
- W4200406161 cites W2114186198 @default.
- W4200406161 cites W2117170342 @default.
- W4200406161 cites W2120377442 @default.
- W4200406161 cites W2120704640 @default.
- W4200406161 cites W2124364749 @default.
- W4200406161 cites W2129307238 @default.
- W4200406161 cites W2131852221 @default.
- W4200406161 cites W2143340044 @default.
- W4200406161 cites W2152119060 @default.
- W4200406161 cites W2153240577 @default.
- W4200406161 cites W2166336042 @default.
- W4200406161 cites W2166511841 @default.
- W4200406161 cites W2168451285 @default.
- W4200406161 cites W2191292005 @default.
- W4200406161 cites W2207268297 @default.
- W4200406161 cites W2255138985 @default.
- W4200406161 cites W2277126095 @default.
- W4200406161 cites W2296416881 @default.
- W4200406161 cites W2314634699 @default.
- W4200406161 cites W2461849275 @default.
- W4200406161 cites W2468521850 @default.
- W4200406161 cites W2480884242 @default.
- W4200406161 cites W2516954052 @default.
- W4200406161 cites W2518595415 @default.
- W4200406161 cites W2592518050 @default.
- W4200406161 cites W2623352127 @default.
- W4200406161 cites W2791897116 @default.
- W4200406161 cites W2803583953 @default.
- W4200406161 cites W2882970870 @default.
- W4200406161 cites W2889787710 @default.
- W4200406161 cites W2908002252 @default.
- W4200406161 cites W2910619319 @default.
- W4200406161 cites W2916749909 @default.
- W4200406161 cites W2920516237 @default.
- W4200406161 cites W2920543411 @default.
- W4200406161 cites W2952845963 @default.
- W4200406161 cites W2954406194 @default.
- W4200406161 cites W2980903814 @default.