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- W4200410664 abstract "Abstract A total of 42 trisubstituted carboranes categorised into five scaffolds were systematically designed and synthesized by exploiting the different reactivities of the twelve vertices of o- , m -, and p -carboranes to cover all directions in chemical space. Significant inhibitors of hypoxia inducible factor transcriptional activitay were mainly observed among scaffold V compounds (e.g., Vi–m , and Vo ), whereas anti-rabies virus activity was observed among scaffold V ( Va–h ), scaffold II ( IIb–g ), and scaffold IV ( IVb ) compounds. The pharmacophore model predicted from compounds with scaffold V, which exhibited significant anti-rabies virus activity, agreed well with compounds IIb–g with scaffold II and compound IVb with scaffold IV. Normalized principal moment of inertia analysis indicated that carboranes with scaffolds I–V cover all regions in the chemical space. Furthermore, the first compounds shown to stimulate the proliferation of the rabies virus were found among scaffold V carboranes." @default.
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- W4200410664 date "2021-12-16" @default.
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- W4200410664 title "Comprehensive exploration of chemical space using trisubstituted carboranes" @default.
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- W4200410664 doi "https://doi.org/10.1038/s41598-021-03459-6" @default.
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