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• W4200411885 endingPage "3443" @default.
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• W4200411885 abstract "Abstract Few studies have reported the clinical presentation, surgical treatment, outcomes and influential factors for patients with epilepsy and Sturge-Weber syndrome. This large-scale retrospective study continuously enrolled 132 patients with Sturge-Weber syndrome and epilepsy from January 2008 to December 2018 at our hospital to analyse their characteristics. Among these patients, 90 underwent epilepsy surgery, and their postoperative 2-year follow-up seizure, cognitive and motor functional outcomes were assessed and analysed. Univariable and multivariable logistic analyses were conducted to explore the influential factors. Among the patients with Sturge-Weber syndrome for whom characteristics were analysed (n = 132), 76.52% of patients had their first epileptic seizures within their first year of life. The risk factors for cognitive decline were seizure history ≥ 2 years [adjusted odds ratio (aOR) = 3.829, 95% confidence interval (CI): 1.810–9.021, P = 0.008)], bilateral leptomeningeal angiomas (aOR = 3.173, 95% CI: 1.970–48.194, P = 0.013), age at onset &lt;1 year (aOR = 2.903, 95% CI: 1.230–6.514, P = 0.013), brain calcification (aOR = 2.375, 95% CI: 1.396–5.201, P = 0.021) and left leptomeningeal angiomas (aOR = 2.228, 95% CI: 1.351–32.571, P = 0.030). Of the patients who underwent epilepsy surgery (n = 90), 44 were subject to focal resection, and 46 underwent hemisphere surgery (19 anatomical hemispherectomies and 27 modified hemispherotomies). A postoperative seizure-free status, favourable cognitive outcomes, and favourable motor outcomes were achieved in 83.33%, 44.44% and 43.33% of surgical patients, respectively. The modified hemispherotomy group had similar surgical outcomes, less intraoperative blood loss and shorter postoperative hospital stays than the anatomical hemispherectomy group. Regarding seizure outcomes, full resection (aOR = 11.115, 95% CI: 1.260–98.067, P = 0.020) and age at surgery &lt; 2 years (aOR = 6.040, 95% CI: 1.444–73.367, P = 0.031) were positive influential factors for focal resection. Age at surgery &lt; 2 years (aOR = 15.053, 95% CI: 1.050–215.899, P = 0.036) and infrequent seizures (aOR = 8.426, 95% CI: 1.086–87.442, P = 0.042; monthly versus weekly) were positive influential factors for hemisphere surgery. In conclusion, epilepsy surgery resulted in a good postoperative seizure-free rate and favourable cognitive and motor functional outcomes and showed acceptable safety for patients with epilepsy and Sturge-Weber syndrome. Modified hemispherotomy is a less invasive and safer type of hemisphere surgery than traditional anatomic hemispherectomy with similar surgical outcomes. Early surgery may be helpful to achieve better seizure outcomes and cognitive protection, while the risk of surgery for young children should also be considered." @default.
• W4200411885 created "2021-12-31" @default.
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• W4200411885 date "2021-12-21" @default.
• W4200411885 modified "2023-09-25" @default.
• W4200411885 title "Characteristics, surgical outcomes, and influential factors of epilepsy in Sturge-Weber syndrome" @default.
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