FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200412273> ?p ?o ?g. }

• W4200412273 endingPage "2768" @default.
• W4200412273 startingPage "2757" @default.
• W4200412273 abstract "Prophylactic treatment of haemophilia A patients with factor VIII (FVIII) concentrate focuses on maintaining a minimal trough FVIII activity level to prevent bleeding. However, due to differences in bleeding tendency, the pharmacokinetic (PK)-guided dosing approach may be suboptimal. An alternative approach could be the addition of haemostatic pharmacodynamic (PD) parameters, reflecting a patient's unique haemostatic balance. Our aim was to develop a population PK/PD model, based on FVIII activity levels and Nijmegen Haemostasis Assay (NHA) patterns, a global haemostatic assay that measures thrombin/plasmin generation simultaneously.PK/PD measurements were collected from 30 patients treated with standard half-life FVIII concentrate. The relationship between FVIII activity levels and the thrombin/plasmin generation parameters (thrombin potential, thrombin peak height and plasmin peak height), were described by sigmoidal Emax functions.The obtained EC50 value was smallest for the normalized thrombin potential (11.6 IU/dL), followed by normalized thrombin peak height (56.6 IU/dL) and normalized plasmin peak height (593 IU/dL), demonstrating that normalized thrombin potential showed 50% of the maximal effect at lower FVIII activity levels. Substantial inter-individual variability in the PD parameters, such as EC50 of thrombin potential (86.9%) was observed, indicating that, despite similar FVIII activity levels, haemostatic capacity varies significantly between patients.These data suggest that dosing based on patients' individual PK/PD parameters may be beneficial over dosing solely on individual PK parameters. This model could be used as proof-of-principle to examine the application of PK/PD-guided dosing. However, the relation between the PD parameters and bleeding has to be better defined." @default.
• W4200412273 created "2021-12-31" @default.
• W4200412273 creator A5021986417 @default.
• W4200412273 creator A5034484228 @default.
• W4200412273 creator A5037222042 @default.
• W4200412273 creator A5043026808 @default.
• W4200412273 creator A5054098878 @default.
• W4200412273 creator A5067266121 @default.
• W4200412273 creator A5077074281 @default.
• W4200412273 creator A5085526211 @default.
• W4200412273 creator A5088172923 @default.
• W4200412273 date "2022-01-15" @default.
• W4200412273 modified "2023-09-25" @default.
• W4200412273 title "Combining factor VIII levels and thrombin/plasmin generation: A population pharmacokinetic‐pharmacodynamic model for patients with haemophilia A" @default.
• W4200412273 cites W1482853338 @default.
• W4200412273 cites W1895185717 @default.
• W4200412273 cites W1985887837 @default.
• W4200412273 cites W1986601719 @default.
• W4200412273 cites W2008550866 @default.
• W4200412273 cites W2014705050 @default.
• W4200412273 cites W2026502021 @default.
• W4200412273 cites W2033408014 @default.
• W4200412273 cites W2045886098 @default.
• W4200412273 cites W2066569278 @default.
• W4200412273 cites W2067732954 @default.
• W4200412273 cites W2072493867 @default.
• W4200412273 cites W2075409267 @default.
• W4200412273 cites W2133535613 @default.
• W4200412273 cites W2149564822 @default.
• W4200412273 cites W2156434340 @default.
• W4200412273 cites W2157418119 @default.
• W4200412273 cites W2167801052 @default.
• W4200412273 cites W2600156320 @default.
• W4200412273 cites W2600562065 @default.
• W4200412273 cites W2608266095 @default.
• W4200412273 cites W2617437014 @default.
• W4200412273 cites W2804969681 @default.
• W4200412273 cites W2806756363 @default.
• W4200412273 cites W2901906050 @default.
• W4200412273 cites W2912772982 @default.
• W4200412273 cites W2944969352 @default.
• W4200412273 cites W3008787870 @default.
• W4200412273 cites W3021084420 @default.
• W4200412273 cites W3047046471 @default.
• W4200412273 cites W3088656094 @default.
• W4200412273 cites W3201244536 @default.
• W4200412273 cites W4200412273 @default.
• W4200412273 doi "https://doi.org/10.1111/bcp.15185" @default.
• W4200412273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34921439" @default.
• W4200412273 hasPublicationYear "2022" @default.
• W4200412273 type Work @default.
• W4200412273 citedByCount "4" @default.
• W4200412273 countsByYear W42004122732022 @default.
• W4200412273 countsByYear W42004122732023 @default.
• W4200412273 crossrefType "journal-article" @default.
• W4200412273 hasAuthorship W4200412273A5021986417 @default.
• W4200412273 hasAuthorship W4200412273A5034484228 @default.
• W4200412273 hasAuthorship W4200412273A5037222042 @default.
• W4200412273 hasAuthorship W4200412273A5043026808 @default.
• W4200412273 hasAuthorship W4200412273A5054098878 @default.
• W4200412273 hasAuthorship W4200412273A5067266121 @default.
• W4200412273 hasAuthorship W4200412273A5077074281 @default.
• W4200412273 hasAuthorship W4200412273A5085526211 @default.
• W4200412273 hasAuthorship W4200412273A5088172923 @default.
• W4200412273 hasBestOaLocation W42004122731 @default.
• W4200412273 hasConcept C111113717 @default.
• W4200412273 hasConcept C112705442 @default.
• W4200412273 hasConcept C126322002 @default.
• W4200412273 hasConcept C141071460 @default.
• W4200412273 hasConcept C181199279 @default.
• W4200412273 hasConcept C185592680 @default.
• W4200412273 hasConcept C2777232031 @default.
• W4200412273 hasConcept C2777288759 @default.
• W4200412273 hasConcept C2777292125 @default.
• W4200412273 hasConcept C2778385053 @default.
• W4200412273 hasConcept C2781071845 @default.
• W4200412273 hasConcept C2908647359 @default.
• W4200412273 hasConcept C3018972837 @default.
• W4200412273 hasConcept C55493867 @default.
• W4200412273 hasConcept C71924100 @default.
• W4200412273 hasConcept C89560881 @default.
• W4200412273 hasConcept C98274493 @default.
• W4200412273 hasConcept C99454951 @default.
• W4200412273 hasConceptScore W4200412273C111113717 @default.
• W4200412273 hasConceptScore W4200412273C112705442 @default.
• W4200412273 hasConceptScore W4200412273C126322002 @default.
• W4200412273 hasConceptScore W4200412273C141071460 @default.
• W4200412273 hasConceptScore W4200412273C181199279 @default.
• W4200412273 hasConceptScore W4200412273C185592680 @default.
• W4200412273 hasConceptScore W4200412273C2777232031 @default.
• W4200412273 hasConceptScore W4200412273C2777288759 @default.
• W4200412273 hasConceptScore W4200412273C2777292125 @default.
• W4200412273 hasConceptScore W4200412273C2778385053 @default.
• W4200412273 hasConceptScore W4200412273C2781071845 @default.
• W4200412273 hasConceptScore W4200412273C2908647359 @default.
• W4200412273 hasConceptScore W4200412273C3018972837 @default.
• W4200412273 hasConceptScore W4200412273C55493867 @default.
• W4200412273 hasConceptScore W4200412273C71924100 @default.

• next