FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200412501> ?p ?o ?g. }

• W4200412501 endingPage "866" @default.
• W4200412501 startingPage "856" @default.
• W4200412501 abstract "The optimal choice of biological agents after failure of anti-tumour-necrosis-factor-(TNF)α agent in Crohn's disease (CD) is yet to be defined.To assess the effectiveness and safety of ustekinumab compared to vedolizumab as second-line treatment in CD patients who failed anti-TNFα therapy.Retrospective analysis of clinical response and remission at 14 and 52 weeks to ustekinumab by physician global assessment (PGA). A propensity score-matched analysis with a cohort treated with vedolizumab was performed.Of 282 patients (mean age 40 ± 15, F:M ratio 1.7:1) treated with ustekinumab, clinical response or remission was reached by 200/282 patients (70.9%) at 14 weeks, and 162/259 patients (62.5%) at 52 weeks. Overall, 74 adverse events occurred, of which 26 were labelled as serious (8.3 per 100 person-year). After exclusion of patients without prior anti-TNFα exposure and patients previously exposed to vedolizumab or ustekinumab, we analysed 275/282 patients (97.5%) on ustekinumab and 118/135 patients (87.4%) on vedolizumab. Propensity score analysis revealed that at 14 weeks, patients treated with ustekinumab were 38% (95% CI 25%-50%; P < 0.001) more likely to achieve clinical remission, while at 52 weeks, the difference of 9% (95% CI -15% to 33%; P = 0.462) was not significant.Ustekinumab was effective and well tolerated in this real-world cohort. While ustekinumab proved more effective at 14-weeks, we found no statistically significant differences at 52 weeks compared to vedolizumab." @default.
• W4200412501 created "2021-12-31" @default.
• W4200412501 creator A5005904384 @default.
• W4200412501 creator A5006030450 @default.
• W4200412501 creator A5007165704 @default.
• W4200412501 creator A5010149242 @default.
• W4200412501 creator A5011340986 @default.
• W4200412501 creator A5020457957 @default.
• W4200412501 creator A5024152188 @default.
• W4200412501 creator A5024729975 @default.
• W4200412501 creator A5029371369 @default.
• W4200412501 creator A5033101682 @default.
• W4200412501 creator A5040250172 @default.
• W4200412501 creator A5044794723 @default.
• W4200412501 creator A5056399853 @default.
• W4200412501 creator A5060861593 @default.
• W4200412501 creator A5063242123 @default.
• W4200412501 creator A5074260199 @default.
• W4200412501 creator A5076399657 @default.
• W4200412501 creator A5076631930 @default.
• W4200412501 creator A5083365995 @default.
• W4200412501 creator A5089273298 @default.
• W4200412501 creator A5089502195 @default.
• W4200412501 date "2021-12-22" @default.
• W4200412501 modified "2023-10-17" @default.
• W4200412501 title "A propensity score‐matched, real‐world comparison of ustekinumab vs vedolizumab as a second‐line treatment for Crohn’s disease. The Cross Pennine study II" @default.
• W4200412501 cites W1878621938 @default.
• W4200412501 cites W1973977312 @default.
• W4200412501 cites W1996158630 @default.
• W4200412501 cites W2077531651 @default.
• W4200412501 cites W2089594729 @default.
• W4200412501 cites W2324298557 @default.
• W4200412501 cites W2336136362 @default.
• W4200412501 cites W2593531649 @default.
• W4200412501 cites W2597769394 @default.
• W4200412501 cites W2751640077 @default.
• W4200412501 cites W2757742334 @default.
• W4200412501 cites W2783970348 @default.
• W4200412501 cites W2786821373 @default.
• W4200412501 cites W2883309804 @default.
• W4200412501 cites W2885490300 @default.
• W4200412501 cites W2887951414 @default.
• W4200412501 cites W2888061430 @default.
• W4200412501 cites W2891495287 @default.
• W4200412501 cites W2949132681 @default.
• W4200412501 cites W2951164569 @default.
• W4200412501 cites W2952365135 @default.
• W4200412501 cites W2984128211 @default.
• W4200412501 cites W2993856613 @default.
• W4200412501 cites W2995726288 @default.
• W4200412501 cites W2997639160 @default.
• W4200412501 cites W3001878407 @default.
• W4200412501 cites W3014519973 @default.
• W4200412501 cites W3014838615 @default.
• W4200412501 cites W3022073735 @default.
• W4200412501 cites W3027973540 @default.
• W4200412501 cites W3047788886 @default.
• W4200412501 cites W3082374255 @default.
• W4200412501 cites W3085289471 @default.
• W4200412501 cites W3094728365 @default.
• W4200412501 cites W3115550355 @default.
• W4200412501 cites W3117032355 @default.
• W4200412501 cites W3122539111 @default.
• W4200412501 cites W3128324972 @default.
• W4200412501 cites W3159272838 @default.
• W4200412501 cites W3199775394 @default.
• W4200412501 cites W4200412501 @default.
• W4200412501 cites W4211153467 @default.
• W4200412501 cites W4211167126 @default.
• W4200412501 cites W4233817719 @default.
• W4200412501 doi "https://doi.org/10.1111/apt.16742" @default.
• W4200412501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34935160" @default.
• W4200412501 hasPublicationYear "2021" @default.
• W4200412501 type Work @default.
• W4200412501 citedByCount "15" @default.
• W4200412501 countsByYear W42004125012021 @default.
• W4200412501 countsByYear W42004125012022 @default.
• W4200412501 countsByYear W42004125012023 @default.
• W4200412501 crossrefType "journal-article" @default.
• W4200412501 hasAuthorship W4200412501A5005904384 @default.
• W4200412501 hasAuthorship W4200412501A5006030450 @default.
• W4200412501 hasAuthorship W4200412501A5007165704 @default.
• W4200412501 hasAuthorship W4200412501A5010149242 @default.
• W4200412501 hasAuthorship W4200412501A5011340986 @default.
• W4200412501 hasAuthorship W4200412501A5020457957 @default.
• W4200412501 hasAuthorship W4200412501A5024152188 @default.
• W4200412501 hasAuthorship W4200412501A5024729975 @default.
• W4200412501 hasAuthorship W4200412501A5029371369 @default.
• W4200412501 hasAuthorship W4200412501A5033101682 @default.
• W4200412501 hasAuthorship W4200412501A5040250172 @default.
• W4200412501 hasAuthorship W4200412501A5044794723 @default.
• W4200412501 hasAuthorship W4200412501A5056399853 @default.
• W4200412501 hasAuthorship W4200412501A5060861593 @default.
• W4200412501 hasAuthorship W4200412501A5063242123 @default.
• W4200412501 hasAuthorship W4200412501A5074260199 @default.
• W4200412501 hasAuthorship W4200412501A5076399657 @default.
• W4200412501 hasAuthorship W4200412501A5076631930 @default.
• W4200412501 hasAuthorship W4200412501A5083365995 @default.

• next