Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200413151> ?p ?o ?g. }
- W4200413151 abstract "Neuronal processing is energy demanding and relies on sugar metabolism. To nurture the Drosophila nervous system, the blood-brain barrier forming glial cells take up trehalose from the hemolymph and then distribute the metabolic products further to all neurons. This function is provided by glucose and lactate transporters of the solute carrier (SLC) 5A family. Here we identified three SLC5A genes that are specifically expressed in overlapping sets of CNS glial cells, rumpel, bumpel and kumpel. We generated mutants in all genes and all mutants are viable and fertile, lacking discernible phenotypes. Loss of rumpel causes subtle locomotor phenotypes and flies display increased daytime sleep. In addition, in bumpel kumpel double mutants, and to an even greater extent in rumpel bumpel kumpel triple mutants, oogenesis is disrupted at the onset of the vitollegenic phase. This indicates a partially redundant function between these genes. Rescue experiments exploring this effect indicate that oogenesis can be affected by CNS glial cells. Moreover, expression of heterologous mammalian SLC5A transporters, with known transport properties, suggest that Bumpel and/or Kumpel transport glucose or lactate. Overall, our results imply a redundancy in SLC5A nutrient sensing functions in Drosophila glial cells, affecting ovarian development and behavior." @default.
- W4200413151 created "2021-12-31" @default.
- W4200413151 creator A5015870789 @default.
- W4200413151 creator A5022075950 @default.
- W4200413151 creator A5025776843 @default.
- W4200413151 creator A5035028466 @default.
- W4200413151 creator A5046633819 @default.
- W4200413151 creator A5064139321 @default.
- W4200413151 creator A5069408117 @default.
- W4200413151 creator A5083942168 @default.
- W4200413151 creator A5084356476 @default.
- W4200413151 date "2022-01-15" @default.
- W4200413151 modified "2023-10-10" @default.
- W4200413151 title "Redundant functions of the SLC5A transporters Rumpel, Bumpel, and Kumpel in ensheathing glial cells" @default.
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