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- W4200414512 abstract "HBV vaccination effectively prevents HBV transmission and the development of liver cancer. Disease progression and liver-related complications are more common in HIV-1/HBV co-infected than HBV mono-infected individuals. A considerable body of literature, which will be reviewed here, indicates that response to HBV vaccine is suboptimal in HIV-1-infected individuals and that the poor maintenance of protective immunity to HBV vaccines in these individuals is an important medical issue. Several factors affect HBV vaccine response during HIV-1 infection including CD4+ T cell counts, B cell response, vaccine formulation, schedules, and timing of antiretroviral therapy (ART). The initial response to HBV vaccination also plays a critical role in the sustainability of antibody responses in both HIV-1-infected and uninfected vaccinees. Thus, regular follow-up for antibody titer and a booster dose is warranted to prevent HBV transmission in HIV-1 infected people." @default.
- W4200414512 created "2021-12-31" @default.
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- W4200414512 date "2021-12-15" @default.
- W4200414512 modified "2023-10-06" @default.
- W4200414512 title "Undetectable Anti-HBs Antibodies: Need of a Booster Dose for HIV-1-Infected Individuals" @default.
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- W4200414512 doi "https://doi.org/10.3390/vaccines9121484" @default.
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