FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200414984> ?p ?o ?g. }

• W4200414984 endingPage "174683" @default.
• W4200414984 startingPage "174683" @default.
• W4200414984 abstract "Altered mRNA metabolism is a feature of many inflammatory diseases. Post transcriptional regulation of interferon-γ-inducible protein (IP)-10 has been uncharacterized in diabetes conditions. RNA-affinity capture method and RNA immuno-precipitation revealed S100b treatment increased the binding of heterogeneous nuclear ribonucleoprotein (hnRNP)K to the IP-10 3'UTR and increased IP-10 mRNA accumulation. Luciferase activity assay using reporter plasmids showed involvement of IP-10 3'UTR. Knocking down of hnRNPK destabilized S100b induced IP-10 mRNA accumulation. S100b promoted the translocation of hnRNPK from nucleus to the cytoplasm and this was confirmed by phosphomimetic S284/353D mutant and non-phosphatable S284/353A hnRNPK mutant. S100b treatment demethylates hnRNPK at Lys219 by Lysine Specific Demethylase (LSD)-1. HnRNPKK219I, a demethylation defective mutant increased IP-10 mRNA stability. Apparently, triple mutant hnRNPKK219I/S284D/353D promoted IP-10 mRNA stability. Interestingly, knocking down LSD-1 abolished S100b induced IP-10 mRNA accumulation. These observations show for the first time that IP-10 mRNA stability is dynamically regulated by Lysine demethylation of hnRNPK by LSD-1. These results indicate that hnRNPK plays an important role in IP-10 mRNA stability induced by S100b which could exacerbate monocyte activation, relevant to the pathogenesis of diabetic complications like atherosclerosis." @default.
• W4200414984 created "2021-12-31" @default.
• W4200414984 creator A5032432542 @default.
• W4200414984 creator A5044129120 @default.
• W4200414984 creator A5065714055 @default.
• W4200414984 date "2022-04-01" @default.
• W4200414984 modified "2023-10-17" @default.
• W4200414984 title "HnRNPK and lysine specific histone demethylase-1 regulates IP-10 mRNA stability in monocytes" @default.
• W4200414984 cites W1546164714 @default.
• W4200414984 cites W1572011530 @default.
• W4200414984 cites W1580465437 @default.
• W4200414984 cites W1607601839 @default.
• W4200414984 cites W1863307187 @default.
• W4200414984 cites W1965882192 @default.
• W4200414984 cites W1966538534 @default.
• W4200414984 cites W1966747379 @default.
• W4200414984 cites W1976865161 @default.
• W4200414984 cites W1976870292 @default.
• W4200414984 cites W1982925662 @default.
• W4200414984 cites W1988097332 @default.
• W4200414984 cites W1994853655 @default.
• W4200414984 cites W2013529909 @default.
• W4200414984 cites W2016018631 @default.
• W4200414984 cites W2026465178 @default.
• W4200414984 cites W2037257630 @default.
• W4200414984 cites W2039244683 @default.
• W4200414984 cites W2041189065 @default.
• W4200414984 cites W2053123335 @default.
• W4200414984 cites W2057140583 @default.
• W4200414984 cites W2066961705 @default.
• W4200414984 cites W2072677280 @default.
• W4200414984 cites W2073561871 @default.
• W4200414984 cites W2080056304 @default.
• W4200414984 cites W2084605896 @default.
• W4200414984 cites W2084638389 @default.
• W4200414984 cites W2087251851 @default.
• W4200414984 cites W2095969880 @default.
• W4200414984 cites W2096259566 @default.
• W4200414984 cites W2098587915 @default.
• W4200414984 cites W2099209925 @default.
• W4200414984 cites W2111685937 @default.
• W4200414984 cites W2114684563 @default.
• W4200414984 cites W2117233389 @default.
• W4200414984 cites W2122863289 @default.
• W4200414984 cites W2141620979 @default.
• W4200414984 cites W2144013753 @default.
• W4200414984 cites W2147603473 @default.
• W4200414984 cites W2148113734 @default.
• W4200414984 cites W2152804961 @default.
• W4200414984 cites W2156150454 @default.
• W4200414984 cites W2159880035 @default.
• W4200414984 cites W2163351331 @default.
• W4200414984 cites W2166830325 @default.
• W4200414984 cites W2167635085 @default.
• W4200414984 cites W2171502725 @default.
• W4200414984 cites W4239991743 @default.
• W4200414984 doi "https://doi.org/10.1016/j.ejphar.2021.174683" @default.
• W4200414984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34914972" @default.
• W4200414984 hasPublicationYear "2022" @default.
• W4200414984 type Work @default.
• W4200414984 citedByCount "6" @default.
• W4200414984 countsByYear W42004149842022 @default.
• W4200414984 countsByYear W42004149842023 @default.
• W4200414984 crossrefType "journal-article" @default.
• W4200414984 hasAuthorship W4200414984A5032432542 @default.
• W4200414984 hasAuthorship W4200414984A5044129120 @default.
• W4200414984 hasAuthorship W4200414984A5065714055 @default.
• W4200414984 hasConcept C104317684 @default.
• W4200414984 hasConcept C105580179 @default.
• W4200414984 hasConcept C143065580 @default.
• W4200414984 hasConcept C153911025 @default.
• W4200414984 hasConcept C185592680 @default.
• W4200414984 hasConcept C2781364455 @default.
• W4200414984 hasConcept C41282012 @default.
• W4200414984 hasConcept C55493867 @default.
• W4200414984 hasConcept C64927066 @default.
• W4200414984 hasConcept C86803240 @default.
• W4200414984 hasConcept C89604277 @default.
• W4200414984 hasConcept C95444343 @default.
• W4200414984 hasConceptScore W4200414984C104317684 @default.
• W4200414984 hasConceptScore W4200414984C105580179 @default.
• W4200414984 hasConceptScore W4200414984C143065580 @default.
• W4200414984 hasConceptScore W4200414984C153911025 @default.
• W4200414984 hasConceptScore W4200414984C185592680 @default.
• W4200414984 hasConceptScore W4200414984C2781364455 @default.
• W4200414984 hasConceptScore W4200414984C41282012 @default.
• W4200414984 hasConceptScore W4200414984C55493867 @default.
• W4200414984 hasConceptScore W4200414984C64927066 @default.
• W4200414984 hasConceptScore W4200414984C86803240 @default.
• W4200414984 hasConceptScore W4200414984C89604277 @default.
• W4200414984 hasConceptScore W4200414984C95444343 @default.
• W4200414984 hasFunder F4320320717 @default.
• W4200414984 hasLocation W42004149841 @default.
• W4200414984 hasLocation W42004149842 @default.
• W4200414984 hasOpenAccess W4200414984 @default.
• W4200414984 hasPrimaryLocation W42004149841 @default.
• W4200414984 hasRelatedWork W1966512561 @default.
• W4200414984 hasRelatedWork W2012466024 @default.

• next