Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200415411> ?p ?o ?g. }
- W4200415411 abstract "Abstract N,O ‐Diacetyl tyrosine and 3‐(4‐hydroxy‐phenyl)‐propanoic acid were converted into phosphoramidite derivatives and introduced to the 5′‐end of oligonucleotides. The resulting oligonucleotides exhibiting a 4‐hydroxyphenyl alkyl group were conjugated with 4‐phenyl‐1,2,4‐triazoline‐3,5‐dione as a model of a Y‐click reaction. The reaction is fast (<1 h) and efficient (>90 %). A partial side reaction occurred at the C8 position of deoxyguanosine in single‐stranded oligonucleotides. This side reaction does not take place on the G quadruplex and double‐stranded oligonucleotides and when N2 position of guanine is protected. This Y‐click reaction could be applied to 1,2,4‐triazoline‐3,5‐dione derivatives displaying a fluorescent dye, a carbohydrate or orthogonal functions (alkyne, azide, ketone or maleimide) for the labelling of oligonucleotides." @default.
- W4200415411 created "2021-12-31" @default.
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- W4200415411 date "2022-03-10" @default.
- W4200415411 modified "2023-10-18" @default.
- W4200415411 title "Oligonucleotide Conjugation by Tyrosine‐Click Reaction" @default.
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- W4200415411 doi "https://doi.org/10.1002/ejoc.202101361" @default.
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