Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200416403> ?p ?o ?g. }
- W4200416403 abstract "The serendipitous discovery of ketamine's antidepressant effects represents one of the major landmarks in neuropsychopharmacological research of the last 50 years. Ketamine provides an exciting challenge to traditional concepts of antidepressant drug therapy, producing rapid antidepressant effects seemingly without targeting monoaminergic pathways in the conventional way. In consequence, the advent of ketamine has spawned a plethora of neurobiological research into its putative mechanisms. Here, we provide a brief overview of current theories of antidepressant drug action including monoaminergic signaling, disinhibition of glutamatergic neurotransmission, neurotrophic and neuroplastic effects, and how these might relate to ketamine. Given that research into ketamine has not yet yielded new therapies beyond ketamine itself, current knowledge gaps and limitations of available studies are also discussed." @default.
- W4200416403 created "2021-12-31" @default.
- W4200416403 creator A5018128899 @default.
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- W4200416403 creator A5081637436 @default.
- W4200416403 creator A5083239708 @default.
- W4200416403 date "2021-12-03" @default.
- W4200416403 modified "2023-09-30" @default.
- W4200416403 title "Novel Insights Into the Neurobiology of the Antidepressant Response From Ketamine Research: A Mini Review" @default.
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