Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200417281> ?p ?o ?g. }
- W4200417281 endingPage "1825" @default.
- W4200417281 startingPage "1825" @default.
- W4200417281 abstract "Depression is one of the most frequently observed psychological disorders, affecting thoughts, feelings, behavior and a sense of well-being in person. As per the WHO, it is projected to be the primitive cause of various other diseases by 2030. Clinically, depression is treated by various types of synthetic medicines that have several limitations such as side-effects, slow-onset action, poor remission and response rates due to complicated pathophysiology involved with depression. Further, clinically, patients cannot be given the treatment unless it affects adversely the job or family. In addition, synthetic drugs are usually single targeted drugs. Unlike synthetic medicaments, there are many plants that have flavonoids and producing action on multiple molecular targets and exhibit anti-depressant action by affecting multiple neuronal transmissions or pathways such as noradrenergic, serotonergic, GABAnergic and dopaminergic; inhibition of monoamine oxidase and tropomyosin receptor kinase B; simultaneous increase in nerve growth and brain-derived neurotrophic factors. Such herbal drugs with flavonoids are likely to be useful in patients with sub-clinical depression. This review is an attempt to analyze pre-clinical studies, structural activity relationship and characteristics of reported isolated flavonoids, which may be considered for clinical trials for the development of therapeutically useful antidepressant." @default.
- W4200417281 created "2021-12-31" @default.
- W4200417281 creator A5012517356 @default.
- W4200417281 creator A5036129345 @default.
- W4200417281 creator A5067126788 @default.
- W4200417281 creator A5078993116 @default.
- W4200417281 date "2021-12-03" @default.
- W4200417281 modified "2023-09-27" @default.
- W4200417281 title "Emerging Role of Flavonoids as the Treatment of Depression" @default.
- W4200417281 cites W118881033 @default.
- W4200417281 cites W119570941 @default.
- W4200417281 cites W1259376669 @default.
- W4200417281 cites W1516644432 @default.
- W4200417281 cites W1544932752 @default.
- W4200417281 cites W1618134065 @default.
- W4200417281 cites W164848464 @default.
- W4200417281 cites W1734725029 @default.
- W4200417281 cites W1807590635 @default.
- W4200417281 cites W184446568 @default.
- W4200417281 cites W1877874306 @default.
- W4200417281 cites W1878550789 @default.
- W4200417281 cites W1920770718 @default.
- W4200417281 cites W1963940427 @default.
- W4200417281 cites W1964500882 @default.
- W4200417281 cites W1967041070 @default.
- W4200417281 cites W1967498136 @default.
- W4200417281 cites W1970277162 @default.
- W4200417281 cites W1971005475 @default.
- W4200417281 cites W1972306196 @default.
- W4200417281 cites W1972837524 @default.
- W4200417281 cites W1973685719 @default.
- W4200417281 cites W1974149856 @default.
- W4200417281 cites W1974919036 @default.
- W4200417281 cites W1977291689 @default.
- W4200417281 cites W1981017880 @default.
- W4200417281 cites W1981724415 @default.
- W4200417281 cites W1983295831 @default.
- W4200417281 cites W1985031521 @default.
- W4200417281 cites W1986711579 @default.
- W4200417281 cites W1990169758 @default.
- W4200417281 cites W1991829271 @default.
- W4200417281 cites W1993870556 @default.
- W4200417281 cites W1993980712 @default.
- W4200417281 cites W1994034535 @default.
- W4200417281 cites W1994433164 @default.
- W4200417281 cites W1995717578 @default.
- W4200417281 cites W1995897793 @default.
- W4200417281 cites W1996404130 @default.
- W4200417281 cites W1999413322 @default.
- W4200417281 cites W1999445997 @default.
- W4200417281 cites W2003146999 @default.
- W4200417281 cites W2003379103 @default.
- W4200417281 cites W2005839352 @default.
- W4200417281 cites W2006228075 @default.
- W4200417281 cites W2006431138 @default.
- W4200417281 cites W2009054842 @default.
- W4200417281 cites W2009582310 @default.
- W4200417281 cites W2011144770 @default.
- W4200417281 cites W2013109283 @default.
- W4200417281 cites W2014381681 @default.
- W4200417281 cites W2016403812 @default.
- W4200417281 cites W2018655156 @default.
- W4200417281 cites W2019677244 @default.
- W4200417281 cites W2020820423 @default.
- W4200417281 cites W2022858444 @default.
- W4200417281 cites W2023695511 @default.
- W4200417281 cites W2025077660 @default.
- W4200417281 cites W2028515114 @default.
- W4200417281 cites W2028553114 @default.
- W4200417281 cites W2029803700 @default.
- W4200417281 cites W2030737802 @default.
- W4200417281 cites W2030776581 @default.
- W4200417281 cites W2031677268 @default.
- W4200417281 cites W2033898136 @default.
- W4200417281 cites W2035283365 @default.
- W4200417281 cites W2036402050 @default.
- W4200417281 cites W2036618146 @default.
- W4200417281 cites W2039499094 @default.
- W4200417281 cites W2040492629 @default.
- W4200417281 cites W2041170358 @default.
- W4200417281 cites W2043717230 @default.
- W4200417281 cites W2046186483 @default.
- W4200417281 cites W2050887779 @default.
- W4200417281 cites W2053109408 @default.
- W4200417281 cites W2053360005 @default.
- W4200417281 cites W2055073729 @default.
- W4200417281 cites W2055540797 @default.
- W4200417281 cites W2057114546 @default.
- W4200417281 cites W2058482913 @default.
- W4200417281 cites W2061248667 @default.
- W4200417281 cites W2062297242 @default.
- W4200417281 cites W2063755418 @default.
- W4200417281 cites W2063819848 @default.
- W4200417281 cites W2066473579 @default.
- W4200417281 cites W2068144727 @default.
- W4200417281 cites W2069270685 @default.
- W4200417281 cites W2069692485 @default.
- W4200417281 cites W2074602237 @default.