Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200418392> ?p ?o ?g. }
- W4200418392 endingPage "107" @default.
- W4200418392 startingPage "96" @default.
- W4200418392 abstract "Several drugs are chemically unstable in the gastric environment and have low bioavailability restricted by intestinal absorption, which motivates the development of alternative routes for drug release, such as transdermal drug carriers for drug delivery to specific areas of the skin. Herein, novel polyelectrolyte complexes (PEC) consisting of carboxymethylagarose (CMA) and chitosan (CS) were prepared. pH-responsive CMA/CS hydrogels were obtained by mixing CMA and CS at various weight ratios. Swelling ratio was modulated by varying the CMA and CS weight ratio, and the highest swelling values were achieved for 2:1 wt% hydrogels at 25 °C and pH 6.0. PEC films were characterized by ATR-FTIR spectroscopy, TGA, DSC, and SEM. Results indicated that CMA and CS were successfully crosslinked by ionic complexation. As a model drug, diclofenac sodium (DS) was loaded in CMA/CS PECs. Association efficiency and loading capacity were ca. 69% and 79%, respectively, exhibiting 67% cumulative release after 72 h at 37 °C and pH 6.0 through Fickian diffusion mechanism. Viability assay of immortalized human keratinocyte (HaCat) cells showed ca. 100% survival in the presence of hydrogels and DS. Therefore, this work suggests that CMA/CS PECs can be applied as pH-responsive carriers for dermal drug delivery." @default.
- W4200418392 created "2021-12-31" @default.
- W4200418392 creator A5015317246 @default.
- W4200418392 creator A5034945781 @default.
- W4200418392 creator A5035690955 @default.
- W4200418392 creator A5042823232 @default.
- W4200418392 creator A5042921432 @default.
- W4200418392 creator A5057578414 @default.
- W4200418392 creator A5080296248 @default.
- W4200418392 creator A5081214817 @default.
- W4200418392 date "2022-02-01" @default.
- W4200418392 modified "2023-10-03" @default.
- W4200418392 title "Cytocompatible drug delivery hydrogels based on carboxymethylagarose/chitosan pH-responsive polyelectrolyte complexes" @default.
- W4200418392 cites W1971043656 @default.
- W4200418392 cites W1975530828 @default.
- W4200418392 cites W1977072597 @default.
- W4200418392 cites W1998971790 @default.
- W4200418392 cites W1999268473 @default.
- W4200418392 cites W2001119625 @default.
- W4200418392 cites W2003196191 @default.
- W4200418392 cites W2009040121 @default.
- W4200418392 cites W2016277023 @default.
- W4200418392 cites W2017181044 @default.
- W4200418392 cites W2019729163 @default.
- W4200418392 cites W2027926456 @default.
- W4200418392 cites W2032076998 @default.
- W4200418392 cites W2032908044 @default.
- W4200418392 cites W2046304513 @default.
- W4200418392 cites W2047062025 @default.
- W4200418392 cites W2050058120 @default.
- W4200418392 cites W2058371472 @default.
- W4200418392 cites W2060320802 @default.
- W4200418392 cites W2063410512 @default.
- W4200418392 cites W2071825757 @default.
- W4200418392 cites W2081628222 @default.
- W4200418392 cites W2085087801 @default.
- W4200418392 cites W2093006946 @default.
- W4200418392 cites W2101039605 @default.
- W4200418392 cites W2106541681 @default.
- W4200418392 cites W2128880073 @default.
- W4200418392 cites W2130101530 @default.
- W4200418392 cites W2160760798 @default.
- W4200418392 cites W2213430347 @default.
- W4200418392 cites W2263586479 @default.
- W4200418392 cites W2300494568 @default.
- W4200418392 cites W2407287133 @default.
- W4200418392 cites W2466979348 @default.
- W4200418392 cites W2496539870 @default.
- W4200418392 cites W2509172390 @default.
- W4200418392 cites W2518501052 @default.
- W4200418392 cites W2527719646 @default.
- W4200418392 cites W2561665279 @default.
- W4200418392 cites W2595116276 @default.
- W4200418392 cites W2605094439 @default.
- W4200418392 cites W2605158646 @default.
- W4200418392 cites W2606251873 @default.
- W4200418392 cites W2750815580 @default.
- W4200418392 cites W2762555425 @default.
- W4200418392 cites W2766811831 @default.
- W4200418392 cites W2768011551 @default.
- W4200418392 cites W2771121740 @default.
- W4200418392 cites W2773114372 @default.
- W4200418392 cites W2781744415 @default.
- W4200418392 cites W2790398278 @default.
- W4200418392 cites W2792635487 @default.
- W4200418392 cites W2798003679 @default.
- W4200418392 cites W2800381029 @default.
- W4200418392 cites W2800486620 @default.
- W4200418392 cites W2801876579 @default.
- W4200418392 cites W2811416745 @default.
- W4200418392 cites W2896217188 @default.
- W4200418392 cites W2902873355 @default.
- W4200418392 cites W2913445129 @default.
- W4200418392 cites W2927781678 @default.
- W4200418392 cites W2927955149 @default.
- W4200418392 cites W2938370514 @default.
- W4200418392 cites W2943906555 @default.
- W4200418392 cites W2963569724 @default.
- W4200418392 cites W2966749102 @default.
- W4200418392 cites W2966827391 @default.
- W4200418392 cites W2968786318 @default.
- W4200418392 cites W2979533875 @default.
- W4200418392 cites W2982150928 @default.
- W4200418392 cites W2982857678 @default.
- W4200418392 cites W2986949929 @default.
- W4200418392 cites W2989783200 @default.
- W4200418392 cites W2990821864 @default.
- W4200418392 cites W2999768730 @default.
- W4200418392 cites W3010291755 @default.
- W4200418392 cites W3014299867 @default.
- W4200418392 cites W3014999217 @default.
- W4200418392 cites W3019949715 @default.
- W4200418392 cites W3021063945 @default.
- W4200418392 cites W3025753916 @default.
- W4200418392 cites W3033718708 @default.
- W4200418392 cites W3035704702 @default.
- W4200418392 cites W3039525823 @default.
- W4200418392 cites W3040292235 @default.