FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200420352> ?p ?o ?g. }

• W4200420352 endingPage "1038" @default.
• W4200420352 startingPage "1024" @default.
• W4200420352 abstract "Graft-derived cell-free DNA (gdcfDNA) quantification is a promising, minimally invasive tool for detecting acute T cell-mediated rejection (ATCMR) following liver transplantation (LT). We investigated the utility of measuring hepatocyte-specific methylation in cfDNA (HS-cfDNA) to quantify gdcfDNA, examining its accuracy in detecting ATCMR in a prospective, cross-sectional study. Blood was collected from LT recipients immediately prior to graft biopsy for suspected rejection. HS-cfDNA was quantified using droplet-digital polymerase chain reaction. Prebiopsy liver function tests (LFTs) and HS-cfDNA levels were correlated with biopsy results and the primary outcome of treated biopsy-proven acute rejection (tBPAR). A total of 51 patients were recruited; 37 had evidence of rejection on biopsy and 20 required treatment. As much as 11 patients needed inpatient treatment for rejection. HS-cfDNA significantly outperformed LFTs in identifying patients with tBPAR, particularly those needing inpatient treatment (area under the curve, 73.0%; 95% confidence interval, 55.4%-90.6%; P = 0.01). At a threshold of <33.5% of the total cfDNA fraction, HS-cfDNA had a specificity of 97%, correctly excluding tBPAR in 30/31 patients. Quantifying graft-specific methylation in cfDNA has a major advantage over previous gdcfDNA techniques: it does not require genotyping/sequencing, lending it greater feasibility for translation into transplantation care. Low levels of HS-cfDNA were a strong negative predictor for tBPAR (negative predictive value, 86%) and may have a future role in triaging patients prior to invasive graft biopsies." @default.
• W4200420352 created "2021-12-31" @default.
• W4200420352 creator A5001618669 @default.
• W4200420352 creator A5011586454 @default.
• W4200420352 creator A5018079253 @default.
• W4200420352 creator A5022581320 @default.
• W4200420352 creator A5035982101 @default.
• W4200420352 creator A5039616917 @default.
• W4200420352 creator A5045360865 @default.
• W4200420352 creator A5050220299 @default.
• W4200420352 creator A5054693569 @default.
• W4200420352 creator A5058734044 @default.
• W4200420352 creator A5059891436 @default.
• W4200420352 creator A5066345487 @default.
• W4200420352 date "2022-03-21" @default.
• W4200420352 modified "2023-09-30" @default.
• W4200420352 title "Low Levels of Hepatocyte‐Specific Methylation in Cell‐Free DNA Are a Strong Negative Predictor for Acute T Cell–Mediated Rejection Requiring Treatment Following Liver Transplantation" @default.
• W4200420352 cites W1859632889 @default.
• W4200420352 cites W1979833056 @default.
• W4200420352 cites W2064164710 @default.
• W4200420352 cites W2099066165 @default.
• W4200420352 cites W2100462268 @default.
• W4200420352 cites W2100575832 @default.
• W4200420352 cites W2132071692 @default.
• W4200420352 cites W2161855894 @default.
• W4200420352 cites W2253621434 @default.
• W4200420352 cites W2415096995 @default.
• W4200420352 cites W2513682679 @default.
• W4200420352 cites W2528115971 @default.
• W4200420352 cites W2582711321 @default.
• W4200420352 cites W2787491376 @default.
• W4200420352 cites W2794306199 @default.
• W4200420352 cites W2808282032 @default.
• W4200420352 cites W2886223143 @default.
• W4200420352 cites W2896825908 @default.
• W4200420352 cites W2908058925 @default.
• W4200420352 cites W2919929360 @default.
• W4200420352 cites W2937196653 @default.
• W4200420352 cites W2952214509 @default.
• W4200420352 cites W3006475167 @default.
• W4200420352 cites W3108681091 @default.
• W4200420352 cites W3112812734 @default.
• W4200420352 cites W3120393011 @default.
• W4200420352 cites W3165358150 @default.
• W4200420352 doi "https://doi.org/10.1002/lt.26388" @default.
• W4200420352 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34919754" @default.
• W4200420352 hasPublicationYear "2022" @default.
• W4200420352 type Work @default.
• W4200420352 citedByCount "4" @default.
• W4200420352 countsByYear W42004203522022 @default.
• W4200420352 countsByYear W42004203522023 @default.
• W4200420352 crossrefType "journal-article" @default.
• W4200420352 hasAuthorship W4200420352A5001618669 @default.
• W4200420352 hasAuthorship W4200420352A5011586454 @default.
• W4200420352 hasAuthorship W4200420352A5018079253 @default.
• W4200420352 hasAuthorship W4200420352A5022581320 @default.
• W4200420352 hasAuthorship W4200420352A5035982101 @default.
• W4200420352 hasAuthorship W4200420352A5039616917 @default.
• W4200420352 hasAuthorship W4200420352A5045360865 @default.
• W4200420352 hasAuthorship W4200420352A5050220299 @default.
• W4200420352 hasAuthorship W4200420352A5054693569 @default.
• W4200420352 hasAuthorship W4200420352A5058734044 @default.
• W4200420352 hasAuthorship W4200420352A5059891436 @default.
• W4200420352 hasAuthorship W4200420352A5066345487 @default.
• W4200420352 hasConcept C104317684 @default.
• W4200420352 hasConcept C126322002 @default.
• W4200420352 hasConcept C135763542 @default.
• W4200420352 hasConcept C143998085 @default.
• W4200420352 hasConcept C152110520 @default.
• W4200420352 hasConcept C172680121 @default.
• W4200420352 hasConcept C188816634 @default.
• W4200420352 hasConcept C2775934546 @default.
• W4200420352 hasConcept C2777766500 @default.
• W4200420352 hasConcept C2778258057 @default.
• W4200420352 hasConcept C2779234561 @default.
• W4200420352 hasConcept C2779609443 @default.
• W4200420352 hasConcept C2911091166 @default.
• W4200420352 hasConcept C31467283 @default.
• W4200420352 hasConcept C44249647 @default.
• W4200420352 hasConcept C54355233 @default.
• W4200420352 hasConcept C55493867 @default.
• W4200420352 hasConcept C71924100 @default.
• W4200420352 hasConcept C86803240 @default.
• W4200420352 hasConcept C90924648 @default.
• W4200420352 hasConceptScore W4200420352C104317684 @default.
• W4200420352 hasConceptScore W4200420352C126322002 @default.
• W4200420352 hasConceptScore W4200420352C135763542 @default.
• W4200420352 hasConceptScore W4200420352C143998085 @default.
• W4200420352 hasConceptScore W4200420352C152110520 @default.
• W4200420352 hasConceptScore W4200420352C172680121 @default.
• W4200420352 hasConceptScore W4200420352C188816634 @default.
• W4200420352 hasConceptScore W4200420352C2775934546 @default.
• W4200420352 hasConceptScore W4200420352C2777766500 @default.
• W4200420352 hasConceptScore W4200420352C2778258057 @default.
• W4200420352 hasConceptScore W4200420352C2779234561 @default.
• W4200420352 hasConceptScore W4200420352C2779609443 @default.
• W4200420352 hasConceptScore W4200420352C2911091166 @default.
• W4200420352 hasConceptScore W4200420352C31467283 @default.

• next