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- W4200420452 endingPage "1224" @default.
- W4200420452 startingPage "1216" @default.
- W4200420452 abstract "Abstract Primary hyperlipidemias include a heterogeneous set of monogenic and polygenic conditions characterized by a strong family aggregation, severe forms of hypercholesterolemia and/or hypertriglyceridemia, appearance early on life, and a high risk of cardiovascular events and/or recurrent pancreatitis. In real life, a small proportion of the primary hyperlipidemia cases is recognized and treated properly. Our goal is to present an update of current and upcoming therapies for patients with primary hyperlipidemia. Recently, new lipid-lowering medications have obtained authorization from the U.S. Food and Drug Administration and the European Medicines Agency. These drugs target metabolic pathways, including (adenosine 5′-triphosphates)-citrate lyase (bempedoic acid), proprotein convertase subtilisin/kexin 9 (inclisiran), apolipoprotein CIII (volanesorsen), and angiopoietin-like 3 (volanesorsen), that have additive effects with the actions of the currently available therapies (i.e., statins, ezetimibe or fibrates). We discuss the potential clinical indications for the novel medications. To conclude, the addition of these new medications to the therapeutic options for primary hyperlipidemia patients may increase the likelihood of achieving the treatment targets. Also, it could be a safer alternative for patients with side effects for the currently available drugs." @default.
- W4200420452 created "2021-12-31" @default.
- W4200420452 creator A5005019504 @default.
- W4200420452 creator A5038601964 @default.
- W4200420452 creator A5068327011 @default.
- W4200420452 date "2021-12-09" @default.
- W4200420452 modified "2023-10-13" @default.
- W4200420452 title "New Therapies for Primary Hyperlipidemia" @default.
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- W4200420452 doi "https://doi.org/10.1210/clinem/dgab876" @default.