FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200422103> ?p ?o ?g. }

• W4200422103 abstract "Infusions of the short-chain fatty acid (SCFA) acetate in the distal colon improved metabolic parameters in men. Here, we hypothesized that combining rapidly and slowly fermentable fibers will enhance distal colonic acetate production and improve metabolic health. In vitro cultivation studies in a validated model of the colon were used to identify fiber mixtures that yielded high distal colonic acetate production. Subsequently, in two randomized crossover studies, lean and prediabetic overweight/obese men were included. In one study, participants received supplements of either long-chain inulin+resistant starch (INU+RS), INU or maltodextrin (PLA) the day prior to a clinical investigation day (CID). The second trial studied beta glucan+RS (BG+RS) versus BG and PLA. During each CID, breath hydrogen, indirect calorimetry, plasma metabolites/hormones were assessed during fasting and postprandial conditions. Additionally, fecal microbiota composition and SCFA were determined. In prediabetic men, INU+RS increased plasma acetate compared to INU or PLA (P < .05), but did not affect metabolic parameters. In lean men, INU+RS increased breath hydrogen and fasting plasma butyrate, which was accompanied by increased energy expenditure, carbohydrate oxidation and PYY and decreased postprandial glucose concentrations (all P < .05) compared to PLA. BG+RS increased plasma butyrate compared to PLA (P < .05) in prediabetic individuals, but did not affect other fermentation/metabolic markers in both phenotypes. Fiber-induced shifts in fecal microbiota were individual-specific and more pronounced with INU+RS versus BG+RS. Administration of INU+RS (not BG+RS) the day prior to investigation improved metabolic parameters in lean but not in prediabetic individuals, demonstrating that effects were phenotype- and fiber-specific. Further research should study whether longer-term supplementation periods are required to elicit beneficial metabolic health in prediabetic individuals. Trial registration numbers: Clinical trial No. NCT03711383 (Inulin study) and Clinical trial No. NCT03714646 (Beta glucan study)." @default.
• W4200422103 created "2021-12-31" @default.
• W4200422103 creator A5001134583 @default.
• W4200422103 creator A5015350937 @default.
• W4200422103 creator A5017142776 @default.
• W4200422103 creator A5017921511 @default.
• W4200422103 creator A5046794058 @default.
• W4200422103 creator A5048065759 @default.
• W4200422103 creator A5057074180 @default.
• W4200422103 creator A5065850266 @default.
• W4200422103 creator A5081222354 @default.
• W4200422103 creator A5083563194 @default.
• W4200422103 date "2021-12-20" @default.
• W4200422103 modified "2023-10-15" @default.
• W4200422103 title "Fiber mixture-specific effect on distal colonic fermentation and metabolic health in lean but not in prediabetic men" @default.
• W4200422103 cites W1793035576 @default.
• W4200422103 cites W1850288252 @default.
• W4200422103 cites W1967246991 @default.
• W4200422103 cites W1975202380 @default.
• W4200422103 cites W1980329543 @default.
• W4200422103 cites W1983518876 @default.
• W4200422103 cites W1986142882 @default.
• W4200422103 cites W1996056871 @default.
• W4200422103 cites W2020234015 @default.
• W4200422103 cites W2021419192 @default.
• W4200422103 cites W2023615726 @default.
• W4200422103 cites W2034285706 @default.
• W4200422103 cites W2041616502 @default.
• W4200422103 cites W2041811148 @default.
• W4200422103 cites W2048853985 @default.
• W4200422103 cites W2052547316 @default.
• W4200422103 cites W2056279562 @default.
• W4200422103 cites W2057039181 @default.
• W4200422103 cites W2071841602 @default.
• W4200422103 cites W2080283023 @default.
• W4200422103 cites W2096459471 @default.
• W4200422103 cites W2098278200 @default.
• W4200422103 cites W2109392327 @default.
• W4200422103 cites W2109755334 @default.
• W4200422103 cites W2113707020 @default.
• W4200422103 cites W2131501155 @default.
• W4200422103 cites W2132033020 @default.
• W4200422103 cites W2136852526 @default.
• W4200422103 cites W2166073051 @default.
• W4200422103 cites W2170024099 @default.
• W4200422103 cites W2220098999 @default.
• W4200422103 cites W2261667570 @default.
• W4200422103 cites W2298480753 @default.
• W4200422103 cites W2341428856 @default.
• W4200422103 cites W2403780473 @default.
• W4200422103 cites W2409656339 @default.
• W4200422103 cites W2480225869 @default.
• W4200422103 cites W2482094715 @default.
• W4200422103 cites W2508203511 @default.
• W4200422103 cites W2547640677 @default.
• W4200422103 cites W2557766453 @default.
• W4200422103 cites W2604312812 @default.
• W4200422103 cites W2605990004 @default.
• W4200422103 cites W2614800736 @default.
• W4200422103 cites W2775323386 @default.
• W4200422103 cites W2790152383 @default.
• W4200422103 cites W2796439882 @default.
• W4200422103 cites W2800240433 @default.
• W4200422103 cites W2803279161 @default.
• W4200422103 cites W2908821703 @default.
• W4200422103 cites W2910727162 @default.
• W4200422103 cites W2912465744 @default.
• W4200422103 cites W2913914265 @default.
• W4200422103 cites W3001942158 @default.
• W4200422103 cites W3080685158 @default.
• W4200422103 cites W4245710827 @default.
• W4200422103 cites W4254687493 @default.
• W4200422103 doi "https://doi.org/10.1080/19490976.2021.2009297" @default.
• W4200422103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34923911" @default.
• W4200422103 hasPublicationYear "2021" @default.
• W4200422103 type Work @default.
• W4200422103 citedByCount "11" @default.
• W4200422103 countsByYear W42004221032022 @default.
• W4200422103 countsByYear W42004221032023 @default.
• W4200422103 crossrefType "journal-article" @default.
• W4200422103 hasAuthorship W4200422103A5001134583 @default.
• W4200422103 hasAuthorship W4200422103A5015350937 @default.
• W4200422103 hasAuthorship W4200422103A5017142776 @default.
• W4200422103 hasAuthorship W4200422103A5017921511 @default.
• W4200422103 hasAuthorship W4200422103A5046794058 @default.
• W4200422103 hasAuthorship W4200422103A5048065759 @default.
• W4200422103 hasAuthorship W4200422103A5057074180 @default.
• W4200422103 hasAuthorship W4200422103A5065850266 @default.
• W4200422103 hasAuthorship W4200422103A5081222354 @default.
• W4200422103 hasAuthorship W4200422103A5083563194 @default.
• W4200422103 hasBestOaLocation W42004221031 @default.
• W4200422103 hasConcept C100544194 @default.
• W4200422103 hasConcept C126322002 @default.
• W4200422103 hasConcept C134018914 @default.
• W4200422103 hasConcept C142724271 @default.
• W4200422103 hasConcept C185592680 @default.
• W4200422103 hasConcept C204787440 @default.
• W4200422103 hasConcept C27081682 @default.
• W4200422103 hasConcept C2776633847 @default.
• W4200422103 hasConcept C2776979534 @default.

• next