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• W4200422513 abstract "Abstract Homoeologous exchange (HE) is a major mechanism generating post-polyploidization genetic variation with important evolutionary consequences. However, the direct impacts of HE without entangling with additional evolutionary forces on gene expression remains to be fully understood. Here, we analyzed high-throughput RNA-seq data of young leaves from individuals of a synthetic allotetraploid wheat (AADD), which contain variable numbers of HEs. We aimed to investigate if and to which extent HE directly impacts gene expression and alternative splicing (AS). We found that HE impacts expression of genes located within HE regions primarily via cis -acting dosage effect, which led to significant changes in the total expression of homoeolog pairs, especially for homoeologs whose original expression was biased. In parallel, HE influences expression of a large amount of genes residing in non-HE regions by trans -regulation leading to convergent expression of homoeolog pairs. Intriguingly, when taking into account of the original relative homoeolog expression states, homoeolog pairs under trans -effect are more prone to showing convergent response to HE whereas those under cis -effect trended to show subgenome-specific expression. Moreover, HE induced quantitative, largely individual-specific, changes of alternative splicing (AS) events. Like homoeologs expression, homoeo-AS events which related to trans effect were more responsive to HE. HE therefore exerts multifaceted immediate effects on gene expression and, to a less extent, also transcript diversity in nascent allopolyploidy." @default.
• W4200422513 created "2021-12-31" @default.
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• W4200422513 date "2021-12-28" @default.
• W4200422513 modified "2023-09-28" @default.
• W4200422513 title "Effects of homoeologous exchange on gene expression and alternative splicing in a newly formed allotetraploid wheat" @default.
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• W4200422513 doi "https://doi.org/10.1101/2021.12.28.474319" @default.
• W4200422513 hasPublicationYear "2021" @default.
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