FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200422757> ?p ?o ?g. }

• W4200422757 endingPage "390" @default.
• W4200422757 startingPage "378" @default.
• W4200422757 abstract "Vitamin D affects differentiation, maturation, and activation of dendritic cells (DCs). Obesity-related immune dysfunction is associated with metabolic changes in immune cells. Objectives of the study are to investigate the effects of vitamin D and obesity on immune responses and markers related to immunometabolism of bone marrow-derived dendritic cells (BMDCs). Bone marrow cells (BMCs) were isolated from lean and obese mice, and BMDCs were generated by culturing BMCs with rmGM-CSF. BMDCs were treated with 1 or 10 nM of 1,25-dihydroxyvitamin D3 (1,25(OH)2 D3 ), and maturation was induced by LPS (50 ng/ml) stimulation for 24 hr. Cell phenotypes, cytokine productions, and expression of proteins and genes involved in Akt/mTOR signaling pathway and glycolytic pathway were determined. 1,25(OH)2 D3 treatment inhibited differentiation of BMDCs (CD11c+ %), expression of phenotypes related with DC function (MHC class II and CD86) and production of IL-12p70 in both lean and obese mice. The expression of PD-L1 and the ratio of IL-10/IL-12p70 were increased by 1,25(OH)2 D3 . With 1,25(OH)2 D3 treatment, Akt/mTOR signaling pathway was suppressed, and expression of genes related to glycolysis (Glut1, Pfkfb4, and Hif1A) was increased. The upregulation of glycolysis-related genes observed with 1,25(OH)2 D3 treatment seems to be associated with the induction of tolerogenic features of BMDCs from lean and obese mice, and Hif1A seems to have a potential role in conveying the effect of 1,25(OH)2 D3 on glycolysis." @default.
• W4200422757 created "2021-12-31" @default.
• W4200422757 creator A5001826977 @default.
• W4200422757 creator A5015033974 @default.
• W4200422757 creator A5047893733 @default.
• W4200422757 creator A5064829479 @default.
• W4200422757 date "2022-01-10" @default.
• W4200422757 modified "2023-09-24" @default.
• W4200422757 title "The effects of 1,25( <scp>OH</scp> ) <scp> ₂ D ₃ </scp> treatment on immune responses and intracellular metabolic pathways of bone <scp>marrow‐derived</scp> dendritic cells from lean and obese mice" @default.
• W4200422757 cites W1507326555 @default.
• W4200422757 cites W1571896605 @default.
• W4200422757 cites W1593627702 @default.
• W4200422757 cites W1661544713 @default.
• W4200422757 cites W1663317712 @default.
• W4200422757 cites W1749037810 @default.
• W4200422757 cites W1893566975 @default.
• W4200422757 cites W1909009992 @default.
• W4200422757 cites W1918052238 @default.
• W4200422757 cites W1955379330 @default.
• W4200422757 cites W1976239978 @default.
• W4200422757 cites W1978203207 @default.
• W4200422757 cites W1989670144 @default.
• W4200422757 cites W1996235861 @default.
• W4200422757 cites W2000323986 @default.
• W4200422757 cites W2001652786 @default.
• W4200422757 cites W2004851132 @default.
• W4200422757 cites W2005487217 @default.
• W4200422757 cites W2010665897 @default.
• W4200422757 cites W2029081372 @default.
• W4200422757 cites W2033809293 @default.
• W4200422757 cites W2033877575 @default.
• W4200422757 cites W2042849313 @default.
• W4200422757 cites W2052885656 @default.
• W4200422757 cites W2053650844 @default.
• W4200422757 cites W2054828149 @default.
• W4200422757 cites W2064935896 @default.
• W4200422757 cites W2070891612 @default.
• W4200422757 cites W2078553092 @default.
• W4200422757 cites W2088402590 @default.
• W4200422757 cites W2094810151 @default.
• W4200422757 cites W2098912234 @default.
• W4200422757 cites W2100373006 @default.
• W4200422757 cites W2101781154 @default.
• W4200422757 cites W2104464991 @default.
• W4200422757 cites W2104801234 @default.
• W4200422757 cites W2105265356 @default.
• W4200422757 cites W2108279958 @default.
• W4200422757 cites W2110540179 @default.
• W4200422757 cites W2115820946 @default.
• W4200422757 cites W2120129511 @default.
• W4200422757 cites W2143112776 @default.
• W4200422757 cites W2148197020 @default.
• W4200422757 cites W2151488689 @default.
• W4200422757 cites W2155671289 @default.
• W4200422757 cites W2156553521 @default.
• W4200422757 cites W2161144335 @default.
• W4200422757 cites W2162873738 @default.
• W4200422757 cites W2181539302 @default.
• W4200422757 cites W2210729715 @default.
• W4200422757 cites W2327838292 @default.
• W4200422757 cites W2510960647 @default.
• W4200422757 cites W2782754314 @default.
• W4200422757 cites W2808730110 @default.
• W4200422757 cites W2894324859 @default.
• W4200422757 cites W2908700992 @default.
• W4200422757 cites W2912529946 @default.
• W4200422757 cites W2912730947 @default.
• W4200422757 cites W2928592778 @default.
• W4200422757 cites W2942352281 @default.
• W4200422757 cites W2992218627 @default.
• W4200422757 cites W3004104130 @default.
• W4200422757 cites W3195667519 @default.
• W4200422757 doi "https://doi.org/10.1002/iub.2592" @default.
• W4200422757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34962347" @default.
• W4200422757 hasPublicationYear "2022" @default.
• W4200422757 type Work @default.
• W4200422757 citedByCount "5" @default.
• W4200422757 countsByYear W42004227572022 @default.
• W4200422757 countsByYear W42004227572023 @default.
• W4200422757 crossrefType "journal-article" @default.
• W4200422757 hasAuthorship W4200422757A5001826977 @default.
• W4200422757 hasAuthorship W4200422757A5015033974 @default.
• W4200422757 hasAuthorship W4200422757A5047893733 @default.
• W4200422757 hasAuthorship W4200422757A5064829479 @default.
• W4200422757 hasConcept C185592680 @default.
• W4200422757 hasConcept C203014093 @default.
• W4200422757 hasConcept C2776090121 @default.
• W4200422757 hasConcept C2778170410 @default.
• W4200422757 hasConcept C2780007613 @default.
• W4200422757 hasConcept C2781101188 @default.
• W4200422757 hasConcept C62478195 @default.
• W4200422757 hasConcept C86554907 @default.
• W4200422757 hasConcept C86803240 @default.
• W4200422757 hasConcept C8891405 @default.
• W4200422757 hasConcept C95444343 @default.
• W4200422757 hasConceptScore W4200422757C185592680 @default.
• W4200422757 hasConceptScore W4200422757C203014093 @default.
• W4200422757 hasConceptScore W4200422757C2776090121 @default.

• next