Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200422903> ?p ?o ?g. }
- W4200422903 abstract "Autophagy is an evolutionarily conserved lysosomal degradation pathway that maintains metabolism and homeostasis by eliminating protein aggregates and damaged organelles. Many studies have reported that autophagy plays an important role in spinal cord injury (SCI). However, the spatiotemporal patterns of autophagy activation after traumatic SCI are contradictory. Most studies show that the activation of autophagy and inhibition of apoptosis have neuroprotective effects on traumatic SCI. However, reports demonstrate that autophagy is strongly associated with distal neuronal death and the impaired functional recovery following traumatic SCI. This article introduces SCI pathophysiology, the physiology and mechanism of autophagy, and our current review on its role in traumatic SCI. We also discuss the interaction between autophagy and apoptosis and the therapeutic effect of activating or inhibiting autophagy in promoting functional recovery. Thus, we aim to provide a theoretical basis for the biological therapy of SCI." @default.
- W4200422903 created "2021-12-31" @default.
- W4200422903 creator A5033897982 @default.
- W4200422903 creator A5034802972 @default.
- W4200422903 creator A5054358636 @default.
- W4200422903 creator A5071683541 @default.
- W4200422903 creator A5084994726 @default.
- W4200422903 creator A5086632320 @default.
- W4200422903 date "2021-12-20" @default.
- W4200422903 modified "2023-10-14" @default.
- W4200422903 title "Biological Functions and Therapeutic Potential of Autophagy in Spinal Cord Injury" @default.
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