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Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200432843> ?p ?o ?g. }

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• W4200432843 abstract "A series of vanillamides were easily synthesized, exploiting an acyltransferase from Mycobacterium smegmatis (MsAcT). After their evaluation as antimicrobial agents against a panel of Gram-positive and Gram-negative bacteria, three compounds were demonstrated to be 9-fold more effective toward Pseudomonas aeruginosa than the vanillic acid precursor. Taking into consideration the scarce permeability of the Gram-negative bacteria cell envelope when compared to Gram-positive strains or yeasts, these molecules can be considered the basis for the generation of new nature-inspired antimicrobials. To increase the process productivity and avoid any problem related to the poor water solubility of the starting material, a tailored flow biocatalyzed strategy in pure toluene was set up. While a robust immobilization protocol exploiting glyoxyl-agarose was employed to increase the stability of MsAcT, in-line work-up procedures were added downstream the process to enhance the system automation and reduce the overall costs." @default.
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• W4200432843 date "2021-12-29" @default.
• W4200432843 modified "2023-09-30" @default.
• W4200432843 title "Biocatalyzed Synthesis of Vanillamides and Evaluation of Their Antimicrobial Activity" @default.
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• W4200432843 doi "https://doi.org/10.1021/acs.jafc.1c06213" @default.
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