Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200433654> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4200433654 endingPage "224" @default.
- W4200433654 startingPage "219" @default.
- W4200433654 abstract "La prise de médicaments n’est pas dénuée de risques, en particulier dans un contexte de maladie chronique sous-jacente, de spécificités génétiques ou épigénétiques, de mésusage de médicaments, ou en raison d’un défaut d’observance des prescriptions médicales. Le foie, organe central du métabolisme des xénobiotiques est une cible privilégiée de la toxicité médicamenteuse. Celle-ci peut induire des lésions du parenchyme hépatique, associées à une importante morbidité, pouvant conduire à une insuffisance hépatocellulaire aiguë. Prédire la toxicité hépatique des médicaments repose essentiellement sur les études précliniques réalisées dans des modèles animaux. Des modèles alternatifs sont activement recherchés, notamment des systèmes cellulaires capables de récapituler les voies métaboliques de biotransformation et de toxicité des médicaments. Drug administration is not without risk, particularly in the context of an underlying chronic disease, specific genetic and epigenetic background, drug mis(over)use or non-compliance with medical prescriptions. The liver, a central organ of xenobiotic metabolism, is a main target of drug toxicity. This may result in drug-induced liver injuries that can lead to death due to an acute liver failure. Predicting liver toxicity of drugs relies primarily on preclinical studies performed in animal models. Alternative models are therefore actively sought, including cellular systems capable of recapitulating the metabolic pathways of drug biotransformation and toxicity." @default.
- W4200433654 created "2021-12-31" @default.
- W4200433654 creator A5038218994 @default.
- W4200433654 date "2022-02-01" @default.
- W4200433654 modified "2023-09-30" @default.
- W4200433654 title "Modélisation de la toxicité pré-médicamenteuse dans des cultures cellulaires et des organoïdes de foie" @default.
- W4200433654 cites W130546658 @default.
- W4200433654 cites W1967822239 @default.
- W4200433654 cites W1972648266 @default.
- W4200433654 cites W2020592839 @default.
- W4200433654 cites W2027254129 @default.
- W4200433654 cites W2031073731 @default.
- W4200433654 cites W2036331230 @default.
- W4200433654 cites W2052356187 @default.
- W4200433654 cites W2054197186 @default.
- W4200433654 cites W2071356981 @default.
- W4200433654 cites W2077127699 @default.
- W4200433654 cites W2088837725 @default.
- W4200433654 cites W2099882331 @default.
- W4200433654 cites W2104209550 @default.
- W4200433654 cites W2145137957 @default.
- W4200433654 cites W2171534546 @default.
- W4200433654 cites W267691079 @default.
- W4200433654 cites W2805400544 @default.
- W4200433654 cites W2888972338 @default.
- W4200433654 cites W2935769860 @default.
- W4200433654 cites W2958872567 @default.
- W4200433654 cites W2991137874 @default.
- W4200433654 cites W3092088977 @default.
- W4200433654 cites W3112962917 @default.
- W4200433654 doi "https://doi.org/10.1016/j.banm.2021.11.022" @default.
- W4200433654 hasPublicationYear "2022" @default.
- W4200433654 type Work @default.
- W4200433654 citedByCount "0" @default.
- W4200433654 crossrefType "journal-article" @default.
- W4200433654 hasAuthorship W4200433654A5038218994 @default.
- W4200433654 hasBestOaLocation W42004336541 @default.
- W4200433654 hasConcept C126322002 @default.
- W4200433654 hasConcept C151730666 @default.
- W4200433654 hasConcept C2779343474 @default.
- W4200433654 hasConcept C29456083 @default.
- W4200433654 hasConcept C29730261 @default.
- W4200433654 hasConcept C71924100 @default.
- W4200433654 hasConcept C86803240 @default.
- W4200433654 hasConcept C98274493 @default.
- W4200433654 hasConceptScore W4200433654C126322002 @default.
- W4200433654 hasConceptScore W4200433654C151730666 @default.
- W4200433654 hasConceptScore W4200433654C2779343474 @default.
- W4200433654 hasConceptScore W4200433654C29456083 @default.
- W4200433654 hasConceptScore W4200433654C29730261 @default.
- W4200433654 hasConceptScore W4200433654C71924100 @default.
- W4200433654 hasConceptScore W4200433654C86803240 @default.
- W4200433654 hasConceptScore W4200433654C98274493 @default.
- W4200433654 hasIssue "2" @default.
- W4200433654 hasLocation W42004336541 @default.
- W4200433654 hasLocation W42004336542 @default.
- W4200433654 hasOpenAccess W4200433654 @default.
- W4200433654 hasPrimaryLocation W42004336541 @default.
- W4200433654 hasRelatedWork W1999344589 @default.
- W4200433654 hasRelatedWork W2039995305 @default.
- W4200433654 hasRelatedWork W2112727823 @default.
- W4200433654 hasRelatedWork W2156423230 @default.
- W4200433654 hasRelatedWork W2397482356 @default.
- W4200433654 hasRelatedWork W2414453160 @default.
- W4200433654 hasRelatedWork W2789448498 @default.
- W4200433654 hasRelatedWork W2971102090 @default.
- W4200433654 hasRelatedWork W3087591478 @default.
- W4200433654 hasRelatedWork W3204839132 @default.
- W4200433654 hasVolume "206" @default.
- W4200433654 isParatext "false" @default.
- W4200433654 isRetracted "false" @default.
- W4200433654 workType "article" @default.