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- W4200434823 abstract "Abstract BACKGROUND Traditionally, autism spectrum disorder in people with Down syndrome was believed to be uncommon. This misconception is rooted in the challenges that a dual diagnosis poses. In fact, evidence indicates that children with Down syndrome are at risk for autism spectrum disorder with a potentially higher prevalence than the typically developing population. The purpose of this review is to determine the reported prevalence rate of autism spectrum disorder in all individuals with Down syndrome in comparison to the prevalence rate of autism spectrum disorder in the typical population when specific diagnostic tools are used. METHODS We will conduct a systematic review of the prevalence and incidence data and perform a meta-analysis on these results. This study will consider all studies that reported on children and adults with an existing diagnosis of Down syndrome and diagnosed by the standardized assessments for autism spectrum disorder. We will also consider the diagnoses made by team assessment (psychologist, psychiatrist & developmental pediatrician), according to DSM-III, DSM-IV or DSM-V criteria for diagnosing autism spectrum disorder or if they use autism spectrum disorder screeners. Studies will be considered from all countries that have data reporting prevalence on this topic. We will not apply language restrictions, attempting to translate studies that are not in English. We will search five databases (MEDLINE, Embase, PsychINFO, Scopus, and CINAHL). Two reviewers will conduct all screening and data extraction independently. The articles will be categorized according to key findings and a critical appraisal performed. DISCUSSION The results of this review will bring increased awareness of the presence of autism spectrum disorder in individuals with Down syndrome. In doing so, this may facilitate a recommendation for screening and diagnosis for autism spectrum disorder in all individuals with Down syndrome. Based on the research demonstrating the benefits of early identification and intervention on the outcomes of children with autism, we anticipate similar benefits in this population. This will guide the allocation of resources and direct future research. SYSTEMATIC REVIEW REGISTRATION We registerd the review title prospectively on PROSPERO on November 8, 2021. Registration number: CRD42020213282" @default.
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- W4200434823 date "2021-12-29" @default.
- W4200434823 modified "2023-09-28" @default.
- W4200434823 title "Prevalence of Autism Spectrum Disorder (ASD) in all Individuals Diagnosed with Down Syndrome (DS): A Systematic Review and Meta-analysis Protocol" @default.
- W4200434823 doi "https://doi.org/10.21203/rs.3.rs-1171029/v1" @default.
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