Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200435616> ?p ?o ?g. }
- W4200435616 endingPage "1492" @default.
- W4200435616 startingPage "1492" @default.
- W4200435616 abstract "β-lactam-avibactam combinations have been proposed as carbapenem-sparing therapies, but little data exist on their in vitro activities in infections with high bacterial inocula. We investigated the in vitro efficacies and the inoculum effects of ceftazidime-avibactam and aztreonam-avibactam against extended-spectrum β-lactam-resistant Enterobacterales blood isolates. A total of 228 non-repetitive extended-spectrum β-lactam-resistant Escherichia coli and Klebsiella pneumoniae blood isolates were prospectively collected in a tertiary center. In vitro susceptibilities to ceftazidime, aztreonam, meropenem, ceftazidime-avibactam, and aztreonam-avibactam were evaluated by broth microdilution method using standard and high inocula. An inoculum effect was defined as an eightfold or greater increase in MIC when tested with the high inoculum. Of the 228 isolates, 99% were susceptible to ceftazidime-avibactam and 99% had low aztreonam-avibactam MICs (≤8 mg/L). Ceftazidime-avibactam and aztreonam-avibactam exhibited good in vitro activities; MIC50/MIC90 values were 0.5/2 mg/L, 0.125/0.5 mg/L, and ≤0.03/0.25 mg/L, respectively, and aztreonam-avibactam was more active than ceftazidime-avibactam. The frequencies of the inoculum effect with ceftazidime-avibactam and aztreonam-avibactam were lower than with meropenem (14% vs. 38%, p < 0.001 and 30% vs. 38%, p = 0.03, respectively). The β-lactam-avibactam combinations could be useful as carbapenem-sparing strategies, and aztreonam-avibactam has the better in vitro activity but is more subject to the inoculum effect than ceftazidime-avibactam." @default.
- W4200435616 created "2021-12-31" @default.
- W4200435616 creator A5000181495 @default.
- W4200435616 creator A5011578742 @default.
- W4200435616 creator A5017616746 @default.
- W4200435616 creator A5021015067 @default.
- W4200435616 creator A5029983949 @default.
- W4200435616 creator A5035823234 @default.
- W4200435616 creator A5059248855 @default.
- W4200435616 creator A5071325470 @default.
- W4200435616 creator A5078085390 @default.
- W4200435616 creator A5084708203 @default.
- W4200435616 creator A5086479486 @default.
- W4200435616 date "2021-12-05" @default.
- W4200435616 modified "2023-09-26" @default.
- W4200435616 title "In Vitro Activities of Ceftazidime–Avibactam and Aztreonam–Avibactam at Different Inoculum Sizes of Extended-Spectrum β-Lactam-Resistant Enterobacterales Blood Isolates" @default.
- W4200435616 cites W1848317103 @default.
- W4200435616 cites W1921319550 @default.
- W4200435616 cites W1974451627 @default.
- W4200435616 cites W1980538526 @default.
- W4200435616 cites W2013132592 @default.
- W4200435616 cites W2029109260 @default.
- W4200435616 cites W2037851156 @default.
- W4200435616 cites W2058450864 @default.
- W4200435616 cites W2068735589 @default.
- W4200435616 cites W2097999145 @default.
- W4200435616 cites W2108733139 @default.
- W4200435616 cites W2109730521 @default.
- W4200435616 cites W2125858730 @default.
- W4200435616 cites W2131640216 @default.
- W4200435616 cites W2131946678 @default.
- W4200435616 cites W2136706836 @default.
- W4200435616 cites W2137134680 @default.
- W4200435616 cites W2141204124 @default.
- W4200435616 cites W2160228456 @default.
- W4200435616 cites W2163025725 @default.
- W4200435616 cites W2276725448 @default.
- W4200435616 cites W2435544242 @default.
- W4200435616 cites W2470408178 @default.
- W4200435616 cites W2512929917 @default.
- W4200435616 cites W2558942346 @default.
- W4200435616 cites W2713618701 @default.
- W4200435616 cites W2801851274 @default.
- W4200435616 cites W2803965271 @default.
- W4200435616 cites W2892368225 @default.
- W4200435616 cites W2899841051 @default.
- W4200435616 cites W2952960869 @default.
- W4200435616 cites W2989133719 @default.
- W4200435616 cites W3040187407 @default.
- W4200435616 cites W3040595104 @default.
- W4200435616 cites W3040818428 @default.
- W4200435616 cites W3111323253 @default.
- W4200435616 cites W4249066751 @default.
- W4200435616 doi "https://doi.org/10.3390/antibiotics10121492" @default.
- W4200435616 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34943704" @default.
- W4200435616 hasPublicationYear "2021" @default.
- W4200435616 type Work @default.
- W4200435616 citedByCount "1" @default.
- W4200435616 countsByYear W42004356162022 @default.
- W4200435616 crossrefType "journal-article" @default.
- W4200435616 hasAuthorship W4200435616A5000181495 @default.
- W4200435616 hasAuthorship W4200435616A5011578742 @default.
- W4200435616 hasAuthorship W4200435616A5017616746 @default.
- W4200435616 hasAuthorship W4200435616A5021015067 @default.
- W4200435616 hasAuthorship W4200435616A5029983949 @default.
- W4200435616 hasAuthorship W4200435616A5035823234 @default.
- W4200435616 hasAuthorship W4200435616A5059248855 @default.
- W4200435616 hasAuthorship W4200435616A5071325470 @default.
- W4200435616 hasAuthorship W4200435616A5078085390 @default.
- W4200435616 hasAuthorship W4200435616A5084708203 @default.
- W4200435616 hasAuthorship W4200435616A5086479486 @default.
- W4200435616 hasBestOaLocation W42004356161 @default.
- W4200435616 hasConcept C104317684 @default.
- W4200435616 hasConcept C185592680 @default.
- W4200435616 hasConcept C2775933652 @default.
- W4200435616 hasConcept C2776685102 @default.
- W4200435616 hasConcept C2776968632 @default.
- W4200435616 hasConcept C2777058267 @default.
- W4200435616 hasConcept C2777406300 @default.
- W4200435616 hasConcept C2777637488 @default.
- W4200435616 hasConcept C2779631663 @default.
- W4200435616 hasConcept C2780416669 @default.
- W4200435616 hasConcept C501593827 @default.
- W4200435616 hasConcept C523546767 @default.
- W4200435616 hasConcept C54355233 @default.
- W4200435616 hasConcept C547475151 @default.
- W4200435616 hasConcept C55493867 @default.
- W4200435616 hasConcept C71924100 @default.
- W4200435616 hasConcept C86803240 @default.
- W4200435616 hasConcept C89423630 @default.
- W4200435616 hasConcept C94665300 @default.
- W4200435616 hasConceptScore W4200435616C104317684 @default.
- W4200435616 hasConceptScore W4200435616C185592680 @default.
- W4200435616 hasConceptScore W4200435616C2775933652 @default.
- W4200435616 hasConceptScore W4200435616C2776685102 @default.
- W4200435616 hasConceptScore W4200435616C2776968632 @default.
- W4200435616 hasConceptScore W4200435616C2777058267 @default.
- W4200435616 hasConceptScore W4200435616C2777406300 @default.