FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200435927> ?p ?o ?g. }

• W4200435927 endingPage "103662" @default.
• W4200435927 startingPage "103662" @default.
• W4200435927 abstract "In present study, Pd(0) catalysed Suzuki-Miyaura cross coupling reaction was used to synthesize 2,4-biarylphenyl-5-arylthiophene-2-carboxylate (7a–7f) and 2-aryl-4-chlorophenyl-5-arylthiophene-2-carboxylate derivatives (8a–8l) in moderate to good yields. While 2,4-dibromophenyl-5-bromothiophene-2-carboxylate (4) and 2-bromo-4-chlorophenyl-5-bromothiophene-2-carboxylate (5) were synthesized via Steglich esterification of 5-bromothiophene-2-carboxylic acid (1) with 2,4-dibromo phenol (2) and 2-bromo-4-chlorophenol (3) in the presence of N, N΄-dicyclohexylcarbodiimide (DCC) and 4-(dimethylamino)pyridine (DMAP). 1H and 13C NMR were used to confirm all of the compounds. To screen out the most active lead compounds, binding interactions of all synthesized compounds with MurD and MurE Escherichia coli proteins were evaluated theoretically via molecular docking studies indicating the good binding affinities. DFT calculations were performed out by using DFT-B3LYP/3-21g and structural and reactivity parameters were calculated. Compounds 5, 8b, 8e, 8h, and 8j have demonstrated potential reactivities and charge distributions that indicate their efficiency towards biological targets. These chemicals were tested in vitro for antibacterial activity against Gram-negative bacteria (Escherichia coli) at different concentrations based on theoretical results. The total results were quite close to the theoretical predictions and compound 8j was found to be having the greatest potential value, strongest binding affinities, and a promising antibacterial agent with MIC value of 50 mg/ml against Escherichia coli." @default.
• W4200435927 created "2021-12-31" @default.
• W4200435927 creator A5001603720 @default.
• W4200435927 creator A5010158502 @default.
• W4200435927 creator A5020760653 @default.
• W4200435927 creator A5023800408 @default.
• W4200435927 creator A5026801674 @default.
• W4200435927 creator A5043864587 @default.
• W4200435927 creator A5044193886 @default.
• W4200435927 creator A5053673389 @default.
• W4200435927 creator A5054386137 @default.
• W4200435927 creator A5055599349 @default.
• W4200435927 creator A5059767903 @default.
• W4200435927 creator A5061958232 @default.
• W4200435927 creator A5079840544 @default.
• W4200435927 creator A5081549885 @default.
• W4200435927 date "2022-03-01" @default.
• W4200435927 modified "2023-10-18" @default.
• W4200435927 title "Arylation of halogenated thiophene carboxylate via Suzuki–Miyaura reaction: Anti-bacterial study against clinically isolated extensively drug resistant Escherichia coli sequence type 405 and computational investigation" @default.
• W4200435927 cites W1979615637 @default.
• W4200435927 cites W1987186598 @default.
• W4200435927 cites W2003760789 @default.
• W4200435927 cites W2009771981 @default.
• W4200435927 cites W2014286678 @default.
• W4200435927 cites W2023060907 @default.
• W4200435927 cites W2030323464 @default.
• W4200435927 cites W2040215775 @default.
• W4200435927 cites W2050070454 @default.
• W4200435927 cites W2050614267 @default.
• W4200435927 cites W2054295942 @default.
• W4200435927 cites W2059331624 @default.
• W4200435927 cites W2082992748 @default.
• W4200435927 cites W2104168919 @default.
• W4200435927 cites W2105668062 @default.
• W4200435927 cites W2109872885 @default.
• W4200435927 cites W2119612268 @default.
• W4200435927 cites W2120662060 @default.
• W4200435927 cites W2164870496 @default.
• W4200435927 cites W2166682390 @default.
• W4200435927 cites W2171125432 @default.
• W4200435927 cites W2175889513 @default.
• W4200435927 cites W2299759012 @default.
• W4200435927 cites W2510551908 @default.
• W4200435927 cites W2582496387 @default.
• W4200435927 cites W2743607617 @default.
• W4200435927 cites W2798209470 @default.
• W4200435927 cites W2802066628 @default.
• W4200435927 cites W2803350676 @default.
• W4200435927 cites W2806959414 @default.
• W4200435927 cites W2945670062 @default.
• W4200435927 cites W2947004455 @default.
• W4200435927 cites W2951264427 @default.
• W4200435927 cites W2953063768 @default.
• W4200435927 cites W3033839672 @default.
• W4200435927 cites W3096077901 @default.
• W4200435927 cites W3176518245 @default.
• W4200435927 cites W4231649355 @default.
• W4200435927 doi "https://doi.org/10.1016/j.arabjc.2021.103662" @default.
• W4200435927 hasPublicationYear "2022" @default.
• W4200435927 type Work @default.
• W4200435927 citedByCount "2" @default.
• W4200435927 countsByYear W42004359272023 @default.
• W4200435927 crossrefType "journal-article" @default.
• W4200435927 hasAuthorship W4200435927A5001603720 @default.
• W4200435927 hasAuthorship W4200435927A5010158502 @default.
• W4200435927 hasAuthorship W4200435927A5020760653 @default.
• W4200435927 hasAuthorship W4200435927A5023800408 @default.
• W4200435927 hasAuthorship W4200435927A5026801674 @default.
• W4200435927 hasAuthorship W4200435927A5043864587 @default.
• W4200435927 hasAuthorship W4200435927A5044193886 @default.
• W4200435927 hasAuthorship W4200435927A5053673389 @default.
• W4200435927 hasAuthorship W4200435927A5054386137 @default.
• W4200435927 hasAuthorship W4200435927A5055599349 @default.
• W4200435927 hasAuthorship W4200435927A5059767903 @default.
• W4200435927 hasAuthorship W4200435927A5061958232 @default.
• W4200435927 hasAuthorship W4200435927A5079840544 @default.
• W4200435927 hasAuthorship W4200435927A5081549885 @default.
• W4200435927 hasBestOaLocation W42004359271 @default.
• W4200435927 hasConcept C104317684 @default.
• W4200435927 hasConcept C142724271 @default.
• W4200435927 hasConcept C155647269 @default.
• W4200435927 hasConcept C159110408 @default.
• W4200435927 hasConcept C170493617 @default.
• W4200435927 hasConcept C178790620 @default.
• W4200435927 hasConcept C185592680 @default.
• W4200435927 hasConcept C204787440 @default.
• W4200435927 hasConcept C21951064 @default.
• W4200435927 hasConcept C2776910235 @default.
• W4200435927 hasConcept C2778074193 @default.
• W4200435927 hasConcept C2779485729 @default.
• W4200435927 hasConcept C2779953032 @default.
• W4200435927 hasConcept C2780104969 @default.
• W4200435927 hasConcept C2780263894 @default.
• W4200435927 hasConcept C2781076698 @default.
• W4200435927 hasConcept C3018795828 @default.
• W4200435927 hasConcept C41685203 @default.
• W4200435927 hasConcept C523546767 @default.
• W4200435927 hasConcept C54355233 @default.

• next