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- W4200436161 abstract "Abstract Functional neuroimaging research on anxiety has traditionally focused on brain networks associated with the psychological aspects of anxiety. Here, instead, we target the somatic aspects of anxiety. Motivated by the growing appreciation that top-down cortical processing plays a crucial role in perception and action, we used resting-state functional MRI data from the Human Connectome Project and Dynamic Causal Modeling (DCM) to characterize effective connectivity among hierarchically organized regions in the exteroceptive, interoceptive, and motor cortices. In people with high (fear-related) somatic arousal, top-down effective connectivity was enhanced in all three networks: an observation that corroborates well with the phenomenology of anxiety. The anxiety-associated changes in connectivity were sufficiently reliable to predict whether a new participant has mild or severe somatic anxiety. Interestingly, the increase in top-down connections to sensorimotor cortex were not associated with fear affect scores, thus establishing the (relative) dissociation between somatic and cognitive dimensions of anxiety. Overall, enhanced top-down effective connectivity in sensorimotor cortices emerges as a promising and quantifiable candidate marker of trait somatic anxiety." @default.
- W4200436161 created "2021-12-31" @default.
- W4200436161 creator A5007836319 @default.
- W4200436161 creator A5011603896 @default.
- W4200436161 creator A5025997406 @default.
- W4200436161 creator A5076557896 @default.
- W4200436161 date "2021-12-03" @default.
- W4200436161 modified "2023-09-29" @default.
- W4200436161 title "Enhanced top-down sensorimotor processing in somatic anxiety" @default.
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- W4200436161 doi "https://doi.org/10.1101/2021.12.02.471029" @default.
- W4200436161 hasPublicationYear "2021" @default.