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- W4200436559 endingPage "100912" @default.
- W4200436559 startingPage "100912" @default.
- W4200436559 abstract "The prospect of hemophilia patients has dramatically improved in the last few decades with the introduction of various interventions that can effectively treat or prevent their bleeding risk. The life expectancy of patients can now reach that of the healthy population, but this has paved the way for several previously unrecognized morbidities to manifest in older adults with hemophilia. Such clinical complications are attributed to suboptimal management or poor access to effective therapy during childhood as well as chronicity and prolonged exposure to the underlying pathophysiology of the disease and its treatment. Complications common in the aging population are also becoming increasingly relevant in this vulnerable patient subgroup. In this review, we highlight peculiarities of such morbidities including chronic viral infections and liver disease, debilitating joint impairment and bone disease, cardiovascular and chronic kidney disease, and cancers. We also reflect on topics of special interest in adulthood such as sexuality." @default.
- W4200436559 created "2021-12-31" @default.
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- W4200436559 creator A5055062993 @default.
- W4200436559 creator A5060925004 @default.
- W4200436559 creator A5072237761 @default.
- W4200436559 date "2022-05-01" @default.
- W4200436559 modified "2023-10-03" @default.
- W4200436559 title "Clinical burden of hemophilia in older adults: Beyond bleeding risk" @default.
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