Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200436638> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W4200436638 abstract "Abstract Background Septic arthritis is a worse condition of RA that is associated with significant morbidity and mortality. Septic arthritis develops due to direct introduction or invasion of pathogens. The objective of the present study was to formulate Vancomycin hydrochloride-loaded microspheres (VMS) based on Box–Behnken design (BBD) and evaluate its efficacy against septic arthritis. The intraarticular administration of optimized Vancomycin hydrochloride-loaded microspheres (OVMS) can reduce dose size, dosing frequency and systemic exposure with local targeted delivery. Results OVMS was further characterized for its drug–polymer compatibility using differential scanning calorimetry and Fourier transmission infrared spectroscopy. In vitro antibacterial activity was determined using the cup–plate method and in vivo anti-arthritic efficacy was evaluated by gross examination of septic arthritis. DSC and FTIR studies exhibited no interaction or incompatibilities between the drug and polymer. SEM images revealed that OVMS were spherical. It followed the first-order release rate according to Fick's law. The micromeritic properties indicated good flow property of OVMS. The zone of inhibition by OVMS was 1.5 cm against S. aureus . In vivo antibacterial study revealed that OVMS was significant in reducing septic arthritis and bacterial load, i.e., 110.1 CFU/ml in comparison with the control group (850 CFU/ml). Conclusions Thus, OVMS may be used as an effective formulation for the treatment of septic arthritis as compared to marketed IV vancomycin injection after clinical studies." @default.
- W4200436638 created "2021-12-31" @default.
- W4200436638 creator A5003766146 @default.
- W4200436638 creator A5011141240 @default.
- W4200436638 creator A5048023197 @default.
- W4200436638 date "2021-12-01" @default.
- W4200436638 modified "2023-09-26" @default.
- W4200436638 title "DoE approach for development of localized controlled release microspheres of Vancomycin for treatment of septic arthritis" @default.
- W4200436638 cites W130042863 @default.
- W4200436638 cites W1976354109 @default.
- W4200436638 cites W1977408323 @default.
- W4200436638 cites W1982267699 @default.
- W4200436638 cites W1987466091 @default.
- W4200436638 cites W1998162402 @default.
- W4200436638 cites W2011445309 @default.
- W4200436638 cites W2050770454 @default.
- W4200436638 cites W2059839841 @default.
- W4200436638 cites W2093512316 @default.
- W4200436638 cites W2095546988 @default.
- W4200436638 cites W2100664422 @default.
- W4200436638 cites W2130261670 @default.
- W4200436638 cites W2153399964 @default.
- W4200436638 cites W2414713466 @default.
- W4200436638 cites W2586783706 @default.
- W4200436638 cites W2904450205 @default.
- W4200436638 cites W2914625246 @default.
- W4200436638 cites W2981384120 @default.
- W4200436638 cites W3092982640 @default.
- W4200436638 cites W4211054359 @default.
- W4200436638 cites W4211111012 @default.
- W4200436638 doi "https://doi.org/10.1186/s43094-021-00382-5" @default.
- W4200436638 hasPublicationYear "2021" @default.
- W4200436638 type Work @default.
- W4200436638 citedByCount "2" @default.
- W4200436638 countsByYear W42004366382022 @default.
- W4200436638 crossrefType "journal-article" @default.
- W4200436638 hasAuthorship W4200436638A5003766146 @default.
- W4200436638 hasAuthorship W4200436638A5011141240 @default.
- W4200436638 hasAuthorship W4200436638A5048023197 @default.
- W4200436638 hasBestOaLocation W42004366381 @default.
- W4200436638 hasConcept C121332964 @default.
- W4200436638 hasConcept C126322002 @default.
- W4200436638 hasConcept C150903083 @default.
- W4200436638 hasConcept C185592680 @default.
- W4200436638 hasConcept C207001950 @default.
- W4200436638 hasConcept C2775956843 @default.
- W4200436638 hasConcept C2777077863 @default.
- W4200436638 hasConcept C2778980435 @default.
- W4200436638 hasConcept C2779489039 @default.
- W4200436638 hasConcept C39519442 @default.
- W4200436638 hasConcept C501593827 @default.
- W4200436638 hasConcept C523546767 @default.
- W4200436638 hasConcept C54355233 @default.
- W4200436638 hasConcept C55493867 @default.
- W4200436638 hasConcept C71924100 @default.
- W4200436638 hasConcept C86803240 @default.
- W4200436638 hasConcept C97355855 @default.
- W4200436638 hasConcept C98274493 @default.
- W4200436638 hasConceptScore W4200436638C121332964 @default.
- W4200436638 hasConceptScore W4200436638C126322002 @default.
- W4200436638 hasConceptScore W4200436638C150903083 @default.
- W4200436638 hasConceptScore W4200436638C185592680 @default.
- W4200436638 hasConceptScore W4200436638C207001950 @default.
- W4200436638 hasConceptScore W4200436638C2775956843 @default.
- W4200436638 hasConceptScore W4200436638C2777077863 @default.
- W4200436638 hasConceptScore W4200436638C2778980435 @default.
- W4200436638 hasConceptScore W4200436638C2779489039 @default.
- W4200436638 hasConceptScore W4200436638C39519442 @default.
- W4200436638 hasConceptScore W4200436638C501593827 @default.
- W4200436638 hasConceptScore W4200436638C523546767 @default.
- W4200436638 hasConceptScore W4200436638C54355233 @default.
- W4200436638 hasConceptScore W4200436638C55493867 @default.
- W4200436638 hasConceptScore W4200436638C71924100 @default.
- W4200436638 hasConceptScore W4200436638C86803240 @default.
- W4200436638 hasConceptScore W4200436638C97355855 @default.
- W4200436638 hasConceptScore W4200436638C98274493 @default.
- W4200436638 hasIssue "1" @default.
- W4200436638 hasLocation W42004366381 @default.
- W4200436638 hasLocation W42004366382 @default.
- W4200436638 hasOpenAccess W4200436638 @default.
- W4200436638 hasPrimaryLocation W42004366381 @default.
- W4200436638 hasRelatedWork W2063915958 @default.
- W4200436638 hasRelatedWork W2073619436 @default.
- W4200436638 hasRelatedWork W2110064610 @default.
- W4200436638 hasRelatedWork W2111642782 @default.
- W4200436638 hasRelatedWork W2115652721 @default.
- W4200436638 hasRelatedWork W2382345126 @default.
- W4200436638 hasRelatedWork W2389945232 @default.
- W4200436638 hasRelatedWork W2743196984 @default.
- W4200436638 hasRelatedWork W3111707104 @default.
- W4200436638 hasRelatedWork W1482102356 @default.
- W4200436638 hasVolume "7" @default.
- W4200436638 isParatext "false" @default.
- W4200436638 isRetracted "false" @default.
- W4200436638 workType "article" @default.