Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200436691> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4200436691 abstract "Abstract Introduction This study evaluates the anti-diabetic effect of ethanol extract of Stachytarpheta jamaicensis leaf on streptozotocin (STZ) - induced diabetic rats fed on high-fat diet (HFD). Methods Sets of male albino rats of the Wistar strain weighing between 180 and 250 g were exposed to high fat diet (margarine and oil from vegetable sources in a ratio of 2:1 w/v) for 3 weeks. Then the animals were fasted overnight; hyperglycemic state was induced using reduced dose of streptozotocin (35 mg/kg) and animals were randomly divided into five groups ( n = 7); group A received the HFD + STZ (35 mg/kg i.p.); group B received HFD + STZ + gliberclamide (10 mg/kg; i.p); groups C, D and E were administered the HFD + streptozotocin with different doses of the ethanol extract (30, 35 and 100 mg/kg p.o., respectively). Results Results showed significant ( p < 0.05) decrease in blood glucose concentration of the rats treated with different doses of S. jamaicensis extract and those treated with gliberclamide compared to the untreated diabetic rats (negative control). Significant ( p < 0.05) reductions in activities of serum AST, ALP, total protein and bilirubin were noticed in the groups in contrast to the control. Levels of urea, creatinine, potassium and chloride were considerably ( p < 0.05) low while sodium and bicarbonate levels were high in the groups except the control. Lipid profile revealed significant ( p < 0.05) reduction in total cholesterol, triacylglycerol, LDL, VLDL while HDL levels were high in the groups compared to the control. The extract significantly ( p < 0.05) ameliorated weight loss. Histopathology of the liver, kidney and pancreas showed ameliorative effect of the extract against the deleterious changes occasioned by the HFD and STZ induced diabetic state. Conclusion These findings have provided scientific basis for the use of S. jamaicensis in the treatment of diabetes mellitus in ethnomedicinal practices in Nigeria." @default.
- W4200436691 created "2021-12-31" @default.
- W4200436691 creator A5023424778 @default.
- W4200436691 creator A5032555531 @default.
- W4200436691 creator A5041143052 @default.
- W4200436691 date "2021-12-01" @default.
- W4200436691 modified "2023-10-03" @default.
- W4200436691 title "Anti-diabetic effect of Stachytarpheta jamaicensis on low dose streptozotocin-induced diabetic rats fed on a high-fat diet" @default.
- W4200436691 cites W1551849342 @default.
- W4200436691 cites W1937210652 @default.
- W4200436691 cites W1964598896 @default.
- W4200436691 cites W1977862129 @default.
- W4200436691 cites W1980683111 @default.
- W4200436691 cites W1990089345 @default.
- W4200436691 cites W1990650349 @default.
- W4200436691 cites W1990794351 @default.
- W4200436691 cites W2003771230 @default.
- W4200436691 cites W2004291538 @default.
- W4200436691 cites W2017216569 @default.
- W4200436691 cites W2020178790 @default.
- W4200436691 cites W2020267609 @default.
- W4200436691 cites W2024212561 @default.
- W4200436691 cites W2032221348 @default.
- W4200436691 cites W2038846370 @default.
- W4200436691 cites W2039762060 @default.
- W4200436691 cites W2041301244 @default.
- W4200436691 cites W2062002322 @default.
- W4200436691 cites W2077112125 @default.
- W4200436691 cites W2102420760 @default.
- W4200436691 cites W2107462453 @default.
- W4200436691 cites W2109663925 @default.
- W4200436691 cites W2111341687 @default.
- W4200436691 cites W2119922737 @default.
- W4200436691 cites W2222998090 @default.
- W4200436691 cites W2263023695 @default.
- W4200436691 cites W2339830013 @default.
- W4200436691 cites W2725415399 @default.
- W4200436691 cites W2912802963 @default.
- W4200436691 cites W2946247641 @default.
- W4200436691 cites W2996522381 @default.
- W4200436691 cites W3024432354 @default.
- W4200436691 doi "https://doi.org/10.1186/s40816-021-00326-9" @default.
- W4200436691 hasPublicationYear "2021" @default.
- W4200436691 type Work @default.
- W4200436691 citedByCount "2" @default.
- W4200436691 countsByYear W42004366912022 @default.
- W4200436691 crossrefType "journal-article" @default.
- W4200436691 hasAuthorship W4200436691A5023424778 @default.
- W4200436691 hasAuthorship W4200436691A5032555531 @default.
- W4200436691 hasAuthorship W4200436691A5041143052 @default.
- W4200436691 hasBestOaLocation W42004366911 @default.
- W4200436691 hasConcept C126322002 @default.
- W4200436691 hasConcept C134018914 @default.
- W4200436691 hasConcept C2778163477 @default.
- W4200436691 hasConcept C2778270857 @default.
- W4200436691 hasConcept C2779280383 @default.
- W4200436691 hasConcept C2780306776 @default.
- W4200436691 hasConcept C555293320 @default.
- W4200436691 hasConcept C71924100 @default.
- W4200436691 hasConceptScore W4200436691C126322002 @default.
- W4200436691 hasConceptScore W4200436691C134018914 @default.
- W4200436691 hasConceptScore W4200436691C2778163477 @default.
- W4200436691 hasConceptScore W4200436691C2778270857 @default.
- W4200436691 hasConceptScore W4200436691C2779280383 @default.
- W4200436691 hasConceptScore W4200436691C2780306776 @default.
- W4200436691 hasConceptScore W4200436691C555293320 @default.
- W4200436691 hasConceptScore W4200436691C71924100 @default.
- W4200436691 hasIssue "1" @default.
- W4200436691 hasLocation W42004366911 @default.
- W4200436691 hasLocation W42004366912 @default.
- W4200436691 hasOpenAccess W4200436691 @default.
- W4200436691 hasPrimaryLocation W42004366911 @default.
- W4200436691 hasRelatedWork W1995071802 @default.
- W4200436691 hasRelatedWork W2004012005 @default.
- W4200436691 hasRelatedWork W2009443436 @default.
- W4200436691 hasRelatedWork W2011709829 @default.
- W4200436691 hasRelatedWork W2055342276 @default.
- W4200436691 hasRelatedWork W2092993950 @default.
- W4200436691 hasRelatedWork W2095626059 @default.
- W4200436691 hasRelatedWork W2106351911 @default.
- W4200436691 hasRelatedWork W2140892006 @default.
- W4200436691 hasRelatedWork W2158125198 @default.
- W4200436691 hasVolume "7" @default.
- W4200436691 isParatext "false" @default.
- W4200436691 isRetracted "false" @default.
- W4200436691 workType "article" @default.